ArticleJournal of affective disorders2026
Right anterior supramarginal gyrus-cerebellum hyperconnectivity and rumination partially mediate the link between childhood abuse and anger in late-life depression.
Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChildhood abuse is linked to emotional dysregulation and anger across the lifespan, but its neural correlates in late-life depression (LLD) remain unclear.
methodsNinety-eight adults aged ≥60 years with LLD underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan. Childhood abuse (emotional, physical, or sexual) was assessed with the adverse childhood experiences (ACEs) questionnaire, trait anger-hostility with the Revised NEO Personality Inventory (N2), and rumination with the Ruminative Responses Scale. Region of Interest (ROI)-to-ROI resting-state functional connectivity (rs-FC) among 164 atlas regions was compared between participants with and without a history of childhood abuse, controlling for age, gender, education, and depression severity with FDR correction for multiple comparisons. Associations between childhood abuse, rs-FC, and anger were examined using linear regression. Indirect effects were tested with mediation analyses using 5000 bootstrap resamples and bias-corrected confidence intervals.
resultsParticipants with childhood abuse histories (n = 52) showed greater rs-FC in three cortico-cerebellar pathways compared with those without childhood abuse histories (n = 46): right anterior supramarginal gyrus (aSMG)-right cerebellar lobule VI, right inferior frontal gyrus (IFG) pars opercularis-left cerebellar lobule X, and left Heschl's gyrus-right cerebellar lobule VI. Childhood abuse was associated with anger-hostility (p = 0.003). Anger-hostility correlated with each of these rs-FCs, but only aSMG-cerebellum rs-FC remained significant on a multivariate basis. In exploratory parallel mediation analyses (n = 83), this rs-FC and rumination showed significant indirect effects, jointly explaining ~50 % of the association of childhood abuse with anger-hostility.
conclusionsIn LLD, aSMG-cerebellar hyperconnectivity and rumination are parallel pathways linking childhood abuse to chronic anger.
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