Evidence map›Paper›PMID 41407177›Full record

ArticleBone2026

FSH and longitudinal changes in bone marrow adipose tissue composition in older adults.

Tiffany Y Kim, Trisha F Hue, Susan K Ewing, Xiaojuan Li, Sigurdur Sigurdsson, Vilmundur Gudnason, Annegreet G Vlug, Deborah M Kado, Eric Vittinghoff, Karin C Wu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tiffany Y KimEndocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: tiffany.kim@ucsf.edu.
Trisha F HueDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Susan K EwingDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Xiaojuan LiProgram of Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH, USA.
Sigurdur SigurdssonIcelandic Heart Association Research Institute, Kópavogur, Iceland.
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kópavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Annegreet G VlugCenter for Bone Quality, Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Deborah M KadoDepartment of Medicine, Stanford University, Stanford, CA, USA; Geriatric Research Education and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Karin C WuEndocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Eileen H KohDepartment of Medicine, University of Washington, Seattle, WA, USA.
Clifford J RosenCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME, USA.
Mone ZaidiThe Mount Sinai Bone Program and Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ann V SchwartzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Anne L SchaferEndocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

Funding

Targeting FSH for the Therapy of Osteoporosis, Obesity and NeurodegenerationU19AG060917 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Anne Louise Schafer · 2019 to 2026
$29.0M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
Longitudinal changes in marrow fat, other fat depots and boneR01AR065645 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, XIAOJUAN, SCHWARTZ, ANN V · 2014 to 2017
$2.2M
Bone Marrow Adiposity, Bone and Body CompositionR01AR057819 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, XIAOJUAN, SCHWARTZ, ANN V · 2010 to 2012
$1.7M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
CSRD VA IK2 CX001984CSRD VA IK2 CX002765NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR057819NIAMS NIH HHS R01 AR065645NIA NIH HHS N01 AG012100NIA NIH HHS U19 AG060917
6 · The paper itself

Abstract

Bone marrow adipose tissue (BMAT) expansion and distinct BMAT composition profiles, including lower unsaturated levels, are cross-sectionally associated with older age. Prospective changes in BMAT composition with aging and the effect of serum follicle stimulating hormone (FSH), which influences both bone and fat metabolism, are unknown. We examined these associations in the AGES-Reykjavik Bone Marrow Adipose cohort, using sex-stratified linear regression models adjusted for covariates including estradiol and testosterone. At baseline, 236 women and 245 men had mean age 81 (SD 4) and 83 (4) years, respectively. Over a mean 3.3 years for 154 women and 2.6 years for 151 men, there was no significant change in total or saturated BMAT. However, mean unsaturated BMAT increased in women (+0.26 %/year, 95 % CI +0.21 %/year to +0.32 %/year) and men (+0.24 %/year, 95 % CI +0.18 %/year to +0.30 %/year). Among women, greater increases in unsaturated BMAT were associated with significantly greater reductions in vertebral trabecular volumetric BMD. At baseline, women in the highest FSH quartile had highest total (66.6 %, 95 % CI 64.3 %-69.0 %) and saturated BMAT (95 % CI 49.3 %, 47.5 %-51.0 %). No relationship existed between FSH and unsaturated BMAT in women or any BMAT outcome in men. Longitudinally, in women, higher FSH was associated with greater increase in unsaturated BMAT. There was no relationship between FSH and change in total or saturated BMAT in women or any change outcome in men. In older adults, total BMAT was stable, but BMAT composition changed with increases in unsaturated BMAT. In women, higher FSH correlated cross-sectionally with higher saturated BMAT but longitudinally with greater gain in unsaturated BMAT. These novel findings warrant further longitudinal studies to better characterize BMAT changes and the role of FSH.

Indexed as

Adipose TissueBone MarrowFollicle Stimulating HormoneAgedAged, 80 and overAgingFemaleHumansLongitudinal StudiesMaleFollicle Stimulating HormoneAgingBone marrow adipose tissueFollicle stimulating hormoneLipid compositionProspective

Identifiers

PMID41407177
PMCPMC13505319

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.