Evidence map›Paper›PMID 41407207›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma.

Stella Angeli, Constantina Neophytou, Antonia Charalambous, Chrysovalantis Voutouri, Pantelia Themistokleous, Triantafyllos Stylianopoulos, Fotios Mpekris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stella AngeliCancer Genetics, Therapeutics & Ultrastructural Pathology Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus.
Constantina NeophytouCancer Genetics, Therapeutics & Ultrastructural Pathology Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus.
Antonia CharalambousCancer Biophysics Laboratory, Department of Mechanical Engineering, University of Cyprus, Nicosia, 1678, Cyprus.
Chrysovalantis VoutouriCancer Biophysics Laboratory, Department of Mechanical Engineering, University of Cyprus, Nicosia, 1678, Cyprus; AnaBioSi-Data Ltd Company, Nicosia, Cyprus.
Pantelia ThemistokleousCancer Biophysics Laboratory, Department of Mechanical Engineering, University of Cyprus, Nicosia, 1678, Cyprus.
Triantafyllos StylianopoulosCancer Biophysics Laboratory, Department of Mechanical Engineering, University of Cyprus, Nicosia, 1678, Cyprus.
Fotios MpekrisCancer Genetics, Therapeutics & Ultrastructural Pathology Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus. Electronic address: fotiosm@cing.ac.cy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma and dysfunctional vasculature, limiting drug delivery and immune infiltration, while melanoma, though less fibrotic, remains highly metastatic and treatment-resistant. To overcome these barriers, we employed a combinatorial approach repurposing the antihistamine ketotifen with ultrasound-mediated sonopermeation to normalize the Tumor Microenvironment (TME) and enhance chemotherapy efficacy in murine models of PDAC and melanoma. The triple therapy suppressed tumor growth in both models, with pronounced effects in PDAC, where it reduced stiffness, restored vascular function and improved perfusion, alleviated hypoxia, and enhanced T-cell infiltration, compared to untreated controls. Immune activation was confirmed in PDAC, showing increased IL-12p70 and IFN-γ expression, alongside elevated CD8

Indexed as

Antineoplastic AgentsCarcinoma, Pancreatic DuctalMelanomaPancreatic NeoplasmsAnimalsCell Line, TumorDeoxycytidineFemaleHumansMiceMice, Inbred C57BLTumor MicroenvironmentUltrasonic TherapyAntineoplastic AgentsDeoxycytidineChemokinesCytokinesImmune cellsMechanotherapeuticsStroma normalizationUltrasound sonopermeation

Identifiers

PMID41407207
PMCPMC12848565

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.