ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Bence HegyiDepartment of Pharmacology, University of California, Davis, California, United States.ORCID 0000-0003-3113-221X
Logan R J BaileyInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0001-7811-7362
Juliana Mira HernandezDepartment of Pharmacology, University of California, Davis, California, United States.ORCID 0000-0002-6689-4284
Christopher Y KoDepartment of Pharmacology, University of California, Davis, California, United States.ORCID 0000-0002-4539-8222
Erin Y ShenDepartment of Pharmacology, University of California, Davis, California, United States.
Julie BossuytDepartment of Pharmacology, University of California, Davis, California, United States.ORCID 0000-0001-8874-4765
Jennifer M DavisInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0003-2380-1321
Donald M BersDepartment of Pharmacology, University of California, Davis, California, United States.ORCID 0000-0002-2237-9483
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Integrating Transcriptome Reprogramming Into Cardiac Plasticity Regulatory MechanismsR01HL141187 · NHLBI · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis · 2018 to 2026
$4.0M
Uncovering The Mechanogenomic Basis For Cardiac PlasticityR01HL142624 · NHLBI · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis · 2018 to 2026
$3.8M
Regulators of Myofibroblast State Stability & Fibrotic Responsiveness of the HeartR01HL162229 · NHLBI · UNIVERSITY OF WASHINGTON · PI DAVIS, JENNIFER MICHELLE · 2022 to 2025
$2.5M
Phenotype-specific models, mechanisms, and treatment of HFpEFR01HL171057 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Stefano Morotti · 2024 to 2026
$1.8M
Investigating the Role of MBNL1 in Maintaining Cardiomyocyte Terminal Differentiation.F30HL163926 · NHLBI · UNIVERSITY OF WASHINGTON · PI BAILEY, LOGAN ROBERT JEFFERSON · 2022 to 2025
$193k
American Heart Association (AHA) 23CDA1051603Health Resources in Action (HRiA) Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease ResearchHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F30HL163926HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL141084HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL141187HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142282HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142624HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL162229HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171057Ministerio de Ciencia, Tecnología e Innovación (Minciencias) Fulbright Colombia ScholarshipNHLBI NIH HHS R01 HL142282NHLBI NIH HHS R01 HL171057NIDDK NIH HHS P30 DK116074Stanford Diabetes Research Center (SDRC) P30DK116074
6 · The paper itself
Abstract
Heart failure (HF) with preserved ejection fraction (HFpEF) comprises heterogeneous clinical phenotypes and variable comorbidities. Recent two-hit translational animal models, including the hypertensive, nitrosative-stressed mice fed with high-fat diet and l-
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences. · full record | Socratic