Evidence map›Paper›PMID 41407512›Full record

ArticleChemMedChem2026

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice.

Amanda K J P F da Silva, Eucilene K de L B Marques, Lidiane M A de Lima, Widarlane A S Alves, Dayane A Gomes, Pedro L Guzzo, Mônica F Belian, Wagner E Silva, Eduardo C Lira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amanda K J P F da SilvaDepartamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, S/N-Dois Irmãos, Recife-PE, CEP: 52171-900, Brazil.
Eucilene K de L B MarquesDepartamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, S/N-Cidade Universitária, Recife-PE, CEP: 50670-901, Brazil.
Lidiane M A de LimaDepartamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, S/N-Dois Irmãos, Recife-PE, CEP: 52171-900, Brazil.
Widarlane A S AlvesDepartamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, S/N-Cidade Universitária, Recife-PE, CEP: 50670-901, Brazil.
Dayane A GomesDepartamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, S/N-Cidade Universitária, Recife-PE, CEP: 50670-901, Brazil.
Pedro L GuzzoDepartamento de Engenharia de Minas, Centro de Tecnologia, Universidade Federal de Pernambuco, Rua Acadêmico Hélio Ramos, S/N-Cidade Universitária, Recife-PE, CEP: 50740-530, Brazil.
Mônica F BelianDepartamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, S/N-Dois Irmãos, Recife-PE, CEP: 52171-900, Brazil.ORCID https://orcid.org/0000-0001-6545-0246
Wagner E SilvaDepartamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, S/N-Dois Irmãos, Recife-PE, CEP: 52171-900, Brazil.ORCID http://orcid.org/0000-0002-0719-5416
Eduardo C LiraDepartamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, S/N-Cidade Universitária, Recife-PE, CEP: 50670-901, Brazil.

Funding

FACEPE, CAPES and CNPq
6 · The paper itself

Abstract

Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more biocompatible and less toxic systems. Therefore, this work aim to develop a new composition formed by an oxidovanadium(IV) complex as levan. The acute oral toxicity and insulin resistance (IR) are investigated in an animal model using adult Swiss mice treated with daily injections of the synthetic glucocorticoid dexamethasone. The complex is characterized by electronic absorption (λ

Indexed as

Coordination ComplexesFructansHypoglycemic AgentsInsulin ResistanceVanadiumAnimalsBlood GlucoseDexamethasoneDisease Models, AnimalMaleMiceMolecular StructureBlood GlucoseCoordination ComplexesDexamethasoneFructansHypoglycemic AgentsVanadiumdexamethasonediabetes mellitus type 2insulin resistancelevan matrixoxidovanadium(IV) complex

Identifiers

PMID41407512
PMCPMC12913243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.