Evidence map›Paper›PMID 41407554›Full record

ArticleACS synthetic biology2026

Force Transmission by Minimal Focal Adhesion Complexes Induces Synthetic Cell Deformation.

Natalie Huhn, Chiao-Peng Hsu, Timon Nast-Kolb, Arsenii Hordeichyk, Andreas R Bausch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalie HuhnHeinz Nixdorf Chair in Biophysical Engineering of Living Matter, Center for Functional Protein Assemblies, Center for Organoid Systems, Department of Bioscience, Technical University of Munich, Technical University of Munich School of Natural Sciences, Garching 85748, Germany.ORCID 0009-0004-1997-0848
Chiao-Peng HsuHeinz Nixdorf Chair in Biophysical Engineering of Living Matter, Center for Functional Protein Assemblies, Center for Organoid Systems, Department of Bioscience, Technical University of Munich, Technical University of Munich School of Natural Sciences, Garching 85748, Germany.ORCID 0000-0002-6994-7708
Timon Nast-KolbHeinz Nixdorf Chair in Biophysical Engineering of Living Matter, Center for Functional Protein Assemblies, Center for Organoid Systems, Department of Bioscience, Technical University of Munich, Technical University of Munich School of Natural Sciences, Garching 85748, Germany.
Arsenii HordeichykHeinz Nixdorf Chair in Biophysical Engineering of Living Matter, Center for Functional Protein Assemblies, Center for Organoid Systems, Department of Bioscience, Technical University of Munich, Technical University of Munich School of Natural Sciences, Garching 85748, Germany.ORCID 0009-0004-7402-1354
Andreas R BauschHeinz Nixdorf Chair in Biophysical Engineering of Living Matter, Center for Functional Protein Assemblies, Center for Organoid Systems, Department of Bioscience, Technical University of Munich, Technical University of Munich School of Natural Sciences, Garching 85748, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells sense and respond to mechanical cues through focal adhesions-dynamic, multiprotein assemblies linking the actin cytoskeleton to the extracellular matrix. These complexes are essential to processes from cell migration to tissue morphogenesis, yet the minimal physical requirements for their force-transmitting and mechanosensing functions remain unclear. Here, we reconstitute minimal focal adhesion-like complexes in giant unilamellar vesicles (GUVs) using kindlin-2, talin-1, FAK, paxillin, zyxin, and VASP anchored to membranes containing PIP

Indexed as

Artificial CellsFocal AdhesionsActin CytoskeletonActinsActomyosinHumansMechanotransduction, CellularTalinUnilamellar LiposomesZyxinActinsActomyosinTalinUnilamellar LiposomesZyxinactinactomyosincontractile force transmissionfocal adhesionprotein complexreconstitution

Identifiers

PMID41407554
PMCPMC12814769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.