Evidence map›Paper›PMID 41407669›Full record

ArticleNature communications2025

Structural snapshots of Pseudomonas aeruginosa LptB

Francesco Fiorentino, Matteo Cervoni, Yi Wang, Leonhard H Urner, Joshua B Sauer, Anh Tran, Robin A Corey, Dante Rotili, Antonello Mai, Phillip J Stansfeld and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesco FiorentinoDepartment of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-3550-1860
Matteo CervoniDepartment of Science, Roma Tre University, Rome, Italy.ORCID http://orcid.org/0000-0002-4292-2615
Yi WangDepartment of Biology, University of Oxford, Oxford, UK.
Leonhard H UrnerDepartment of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.ORCID http://orcid.org/0000-0001-8144-8955
Joshua B SauerDepartment of Biochemistry, University of Oxford, Oxford, UK.
Anh TranDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Robin A CoreySchool of Physiology, Pharmacology & Neuroscience, University Walk, Bristol, UK.ORCID http://orcid.org/0000-0003-1820-7993
Dante RotiliDepartment of Science, Roma Tre University, Rome, Italy.
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-9176-2382
Phillip J StansfeldSchool of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0001-8800-7669
Francesco ImperiDepartment of Science, Roma Tre University, Rome, Italy.ORCID http://orcid.org/0000-0001-5080-5665
Edward W YuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-5912-1227
Chih-Chia SuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA. cxs670@case.edu.ORCID http://orcid.org/0000-0003-3646-327X
Carol V RobinsonDepartment of Chemistry, University of Oxford, Oxford, UK. carol.robinson@chem.ox.ac.uk.ORCID http://orcid.org/0000-0001-7829-5505
Jani R BollaDepartment of Biology, University of Oxford, Oxford, UK. jani.bolla@biology.ox.ac.uk.ORCID http://orcid.org/0000-0003-4346-182X

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
American Heart Association (American Heart Association, Inc.) 25CDA1455062NCATS NIH HHS UM1 TR004528NCI NIH HHS 75N91019D00024RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P01948X/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/Y003187/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/Y003306/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/T022108/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/Y036158/1RCUK | Medical Research Council (MRC) MR/V028839/1RCUK | Medical Research Council (MRC) MR/Z504245/1Royal Society URF\R1\211567Wellcome TrustWellcome Trust (Wellcome) 208361/Z/17/Z
6 · The paper itself

Abstract

Gram-negative bacteria are intrinsically resistant to many antibiotics because of densely packed lipopolysaccharides (LPS) in the outer leaflet of their outer membrane (OM), which acts as a highly effective barrier towards the spontaneous permeation of toxic molecules, including antibiotics. LPS are extracted from the inner membrane by the ABC transporter LptB

Indexed as

ATP-Binding Cassette TransportersBacterial ProteinsLipopolysaccharidesPseudomonas aeruginosaBiological TransportCryoelectron MicroscopyMolecular Dynamics SimulationPeriplasmProtein BindingATP-Binding Cassette TransportersBacterial ProteinsLipopolysaccharides

Identifiers

PMID41407669
PMCPMC12738788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.