Evidence map›Paper›PMID 41407696›Full record

ArticleNPJ biofilms and microbiomes2025

Intestinal bacteria trigger a hibernation-like state in homotherms via the gut-brain axis.

Ziqiang Bao, Cheng Guo, Yi Chen, Tao Lei, Hua Peng, Han Zhang, Xiaofei Zhang, Ying Ban, Dunwu Qi, Juntao Feng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziqiang BaoInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Cheng GuoInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Yi ChenInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Tao LeiCollege of Life Science and Environment, Central South University of Forestry and Technology, Changsha, Hunan, China.
Hua PengInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Han ZhangInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Xiaofei ZhangInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China.
Ying BanRuoergai Wetland National Nature Reserve Administration, Ruoergai Country, Sichuan, China.
Dunwu QiChengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan, China.
Juntao FengDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China. jtfeng1976@csu.edu.cn.
Zuofu XiangInstitute of Evolutionary Ecology and Conservation Biology, Central South University of Forestry and Technology, Changsha, Hunan, China. xiangzf@csuft.edu.cn.

Funding

National Natural Science Foundation of China 32171487Natural Science Foundation of Hunan Province 2025JJ60191postdoctoral research grants at the Central South University of Forestry and Technology 45220003the State Forestry and Grassland Administration Bureau of China 2019076079
6 · The paper itself

Abstract

The adaptation to low temperature has research value in the fields of spaceflight, disease treatment, and ecological evolution. However, continuous exposure to cold leads to hypothermia and death in homothermic animals. Interestingly, heterothermic animals can easily overcome this challenge. We transferred intestinal bacteria from hibernating Marmota himalayana into mice (homothermic animals) and successfully induced a torpor-like state. The mice exhibited typical characteristics of hibernation (torpor-like), such as the rectal temperature decreased by 3.72-4.58 °C, respiration rate and physical activity were down-regulated, and heat was concentrated in the brown adipose tissue. Those was associated with the Sphingolipid metabolism, regulated by Bacteroides, opened the temperature switch in the medial preoptic area and ventromedial hypothalamus through the "gut-brain axis". Our findings suggested that gut bacteria can regulate thermoregulation via the gut-brain axis and induce animals to adapt to low temperatures in a torpor-like state.

Indexed as

BacteriaBrainGastrointestinal MicrobiomeHibernationMarmotaAdipose Tissue, BrownAnimalsBody TemperatureBody Temperature RegulationCold TemperatureMaleMiceTorpor

Identifiers

PMID41407696
PMCPMC12711890

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.