Evidence map›Paper›PMID 41407862›Full record

ArticleNature2026

Astrocyte CCN1 stabilizes neural circuits in the adult brain.

Laura Sancho, Matthew M Boisvert, Trinity Eddy, Jillybeth Burgado, Minerva Contreras, Lara Labarta-Bajo, Ellen Wang, Lisa Tatsumi, Nicola J Allen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Article
  5. Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Laura SanchoMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Matthew M BoisvertMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Trinity EddyMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jillybeth BurgadoMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Minerva ContrerasMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-9783-9632
Lara Labarta-BajoMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-1812-6704
Ellen WangNeurosciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
Lisa TatsumiBiological Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
Nicola J AllenMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. nallen@salk.edu.ORCID 0000-0002-7542-5930

Funding

Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6M
Targeted Degradation of Extracellular Proteins to Enhance Brain PlasticityDP1NS142487 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Nicola J Allen · 2024 to 2026
$6.7M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Astrocyte regulation of synapse maturationR01NS105742 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALLEN, NICOLA J · 2018 to 2022
$2.4M
Resources for Studying Neural Circuit Structure and Function with G-Deleted Rabies VirusesR24NS092943 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CALLAWAY, EDWARD M · 2015 to 2018
$1.3M
The role of astrocytes in visual critical period plasticityF32EY033629 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SANCHO FERNANDEZ, LAURA · 2022 to 2024
$225k
Dysregulated cholesterol metabolism in Alzheimer's Disease astrocytes: Investigating contributions to neuronal dysfunctionF99NS134205 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURGADO, JILLYBETH · 2023 to 2024
$85k
NEI NIH HHS F32 EY033629NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NINDS NIH HHS DP1 NS142487NINDS NIH HHS F99 NS134205NINDS NIH HHS R01 NS105742NINDS NIH HHS R24 NS092943
6 · The paper itself

Abstract

Neural circuits in many brain regions are refined by experience. Sensory circuits support higher plasticity at younger ages during critical periods-times of circuit refinement and maturation-and limit plasticity in adulthood for circuit stability

Indexed as

AstrocytesBrainCysteine-Rich Protein 61Visual CortexAnimalsCell DifferentiationDominance, OcularFemaleMaleMiceMyelin SheathNeuronal PlasticityNeuronsOligodendrogliaSynapsesCCN1 protein, mouseCysteine-Rich Protein 61

Identifiers

PMID41407862
PMCPMC12823447

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.