ArticleFunctional & integrative genomics2025
Gastrodin extends the lifespan of Caenorhabditis elegans via the DAF-16/FOXO signaling pathway and autophagy.
Article in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Gastrodin alleviates cardiomyocyte senescence by regulating autophagy through the AMPK/mTOR/4EBP1 pathway.Frontiers in pharmacology · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
The progression of age-related pathologies is strongly linked to biological aging. Identifying natural anti-aging agents to mitigate disease onset and development holds substantial therapeutic value. The natural compound Gastrodin (Gas) demonstrates promising effects in retarding aging. This study aims to explore the effects of Gas on the lifespan and antioxidant capacity of Caenorhabditis elegans (C. elegans). Additionally, it seeks to elucidate the possible mechanisms. Initially, Gas was assessed for its influence on C. elegans lifespan, mobility, lipofuscin accumulation, and oxidative stress responses. Subsequent analyses focused on Gas’s modulation of the insulin/IGF-1 pathway, mitochondrial activity, autophagic processes, and gene expression to uncover its lifespan-extending mechanisms. Gas induced a dose-dependent lifespan extension in C. elegans, peaking at 400 µM with a 17.3% increase in longevity. Gas enhanced C. elegans mobility while suppressing age-related lipofuscin deposition.Additionally, Gas lowered ROS levels and elevated antioxidant enzyme activity in C. elegans.Mechanistic studies revealed that Gas’s anti-aging effects rely on transcription factors (DAF-16, SKN-1, HSF-1) and bolster stress resistance via HSPs activation and autophagy induction. This study reveals the potential of Gas in extending the lifespan of C. elegans, emphasizes its mechanism of action by regulating antioxidant capacity, heat stress response, and autophagy pathway, and provides experimental evidence that supports the development of Gas as a candidate compound for lifespan extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.