ReviewLipids in health and disease2025
FABP4 in lipid metabolism and the tumor microenvironment: mechanisms and therapeutic potential.
Review in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Role of lipid-associated fibroblasts and their signature genes FABP4, CD36 and ABCA8 in gastric cancer progression.Oncology letters · 2026Article
- Transcriptomic Profiling of Cutaneous Melanoma Metastases Treated With Microwave Ablation-Pilot Study.Clinical and translational science · 2026Article
- Development and verification of a lipotoxicity-related gene signature for predicting prognosis and immune landscape in colorectal cancer.Discover oncology · 2026Article
- [Mechanisms of Macrophage Efferocytosis-driven Remodeling of Lung Cancer Microenvironment Structure and Angiogenesis and Prospects for Clinical Intervention].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- Decoding early lung adenocarcinoma progression by single-cell and spatial transcriptomics reveals a CMA-related prognostic signature.Frontiers in immunology · 2026Article
- Lipid Metabolic Reprogramming in Breast Cancer: Mechanisms and Emerging Therapeutic Strategies.Breast cancer (Dove Medical Press) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Fatty acid-binding protein 4 (FABP4), a key member of the fatty acid-binding protein family, is involved primarily in fatty acid transport, metabolic regulation, and inflammatory signaling. In recent years, numerous studies have shown that abnormal FABP4 expression in various tumors influences the metabolism of lipids and its metabolic products in tumors, significantly regulating tumor progression through processes such as oxidative stress, epithelial‒mesenchymal transition, angiogenesis, and the immune microenvironment. This review focuses on the role of FABP4 in tumors and systematically elucidates the specific mechanisms through which FABP4 regulates lipid metabolism and alters the tumor microenvironment. This review also provides an in-depth analysis of the complex network relationship between FABP4-mediated lipid metabolism and the tumor microenvironment and reveals the critical role of FABP4 in tumor occurrence, development, and metastasis, offering a new theoretical basis and potential targets for tumor therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.