ArticleJournal of cardiothoracic surgery2025
Clinical predictors of early post-discharge mortality in postmenopausal women with heart failure.
Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to evaluate the clinical characteristics of postmenopausal women diagnosed with heart failure (HF) and to identify prognostic factors associated with mortality during the early post-discharge period-a critical phase marked by increased susceptibility to adverse clinical outcomes.
methodsThis analysis utilized data from the "Research on the Current Status and Trends of Cardiovascular Disease Treatment in Beijing" study, conducted between January 1, 2014, and December 31, 2015. Logistic regression models were applied to identify variables independently associated with short-term post-discharge mortality.
resultsAmong the cohort of postmenopausal women with HF, 78.4% had heart failure with preserved ejection fraction (HFpEF). The prevalence of comorbid coronary artery disease, hypertension, and diabetes mellitus was 50.9%, 74.6%, and 36.1%, respectively. Diastolic blood pressure was negatively associated with 30-day mortality [odds ratio (OR) = 0.97; 95% confidence interval (CI): 0.95-1.00; p < 0.05]. Beta-blocker use was negatively associated with 30-day mortality following discharge [OR = 0.45; 95% CI: 0.28-0.67; p < 0.001]. Age was positively associated with 90-day mortality [OR = 1.05; 95% CI: 1.01-1.11; p < 0.05], while use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) was negatively associated with 90-day mortality [OR = 0.26; 95% CI: 0.06-0.63; p < 0.05].
conclusionPostmenopausal women with HF exhibit distinct clinical characteristics, with a high prevalence of HFpEF and cardiovascular comorbidities. Diastolic blood pressure, age, and the use of beta-blockers and ACEIs/ARBs were identified as significant prognostic factors for short-term mortality during the early post-discharge period. Appropriate management during hospitalization may contribute to reduced mortality risk in this vulnerable timeframe.
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