Evidence map›Paper›PMID 41408676›Full record

ArticleAnnals of medicine2025

Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients.

Jihong Jiang, Xuan Yin, Siyu Kong, Xinchi Li, Fan Yang, Xuesheng Liu, Yali Ge, Jie Sun, Lihai Chen, Hongwei Shi and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jihong JiangDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuan YinSchool of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu, China.
Siyu KongSchool of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu, China.
Xinchi LiSchool of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu, China.
Fan YangSchool of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu, China.
Xuesheng LiuDepartment of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yali GeDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.
Jie SunDepartment of Anesthesiology, Zhongda Hospital, Southeast University, Jiangsu, China.
Lihai ChenDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.ORCID 0000-0001-8535-9239
Hongwei ShiDepartment of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.
Jifang ZhouSchool of International Pharmaceutical Business, China Pharmaceutical University, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative hypotension (IOH) is a prevalent hemodynamic complication associated with adverse postoperative outcomes. Identifying patients at high risk for IOH remains a challenge. Accelerated biological aging, reflecting cumulative physiological decline, may heighten susceptibility to hypotensive events by impairing cardiovascular homeostasis and autonomic regulation, making it a potent yet underutilized predictor in perioperative medicine. MATERIALS AND

methodsThis multicenter retrospective cohort study analyzed 116,996 adults undergoing major cardiac and non-cardiac surgery across three tertiary academic medical centers in Eastern China. Accelerated biological aging was measured using Phenotypic Age Acceleration (PhenoAgeAccel). Outcomes included incidence of IOH (Mean arterial pressure (MAP) < 60 mmHg), cumulative duration, and area under curve (AUC) below this threshold. AUC was calculated using the trapezoidal integration method to quantify the integrated area where MAP < 60 mmHg. Associations were assessed using generalized linear regression, adjusting for key confounders.

resultsAccelerated biological aging was significantly associated with elevated IOH risk (adjusted odds ratio per unit increase 1.04, 95% confidence intervals 1.02-1.06,

conclusionsAccelerated biological aging was significantly associated with both increased risk and greater severity of intraoperative hypotension. These findings support the integration of biological aging metrics, such as PhenoAgeAccel, into preoperative risk assessment to optimize hemodynamic management in vulnerable surgical populations.

Indexed as

AgingAging, PrematureHypotensionIntraoperative ComplicationsSurgical Procedures, OperativeAdultAgedChinaFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk Factorsaccelerated biological agingBiological ageintraoperative hypotensionsurgery

Identifiers

PMID41408676
PMCPMC12716467

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.