Evidence map›Paper›PMID 41408997›Full record

ArticleChemistryOpen2026

Synthesis of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid-Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer.

Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado-Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sunil TivariDepartment of Chemistry, Marwadi University, Rajkot, India.
Naurin LalaniDepartment of Chemistry, Marwadi University, Rajkot, India.
Pritam BagweDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
Prashant ChandoleDepartment of Chemistry, Marwadi University, Rajkot, India.
Ramesh PawarDepartment of Chemistry, Marwadi University, Rajkot, India.
Enrique Delgado-AlvaradoMicro and Nanotechnology Research Center, Universidad Veracruzana, Boca del Río, Mexico.
Abdallah Othman GhnaimDepartment of Chemistry, Faculty of Science, Al-Balqa' Applied University, Salt, Jordan.
Yashwantsinh JadejaDepartment of Chemistry, Marwadi University, Rajkot, India.ORCID https://orcid.org/0000-0002-6072-0654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a leading cause of mortality worldwide, which has led to further research in developing more effective therapeutics. We synthesized amphipathic cationic peptides incorporating 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic acid) into their backbones to explore their potential anticancer properties. The MCF-7 cell line was selected to evaluate cell viability, inhibition percentage, and cytotoxic effects of the synthesized decapeptides. The results suggested DEC-1 (IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsOligopeptidesTetrahydroisoquinolinesCell ProliferationCell SurvivalDrug Screening Assays, AntitumorFemaleHumansKelch-Like ECH-Associated Protein 1MCF-7 CellsMolecular Docking SimulationNF-E2-Related Factor 2Xanthine Oxidase1,2,3,4-tetrahydroisoquinolineAntineoplastic AgentsKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2OligopeptidesTetrahydroisoquinolinesXanthine Oxidaseamphipathic peptidesantiproliferationbreast cancerpeptidestetrahydroisoquinoline

Identifiers

PMID41408997
PMCPMC13052075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.