ArticleBrain and behavior2025
Association of Peripheral Blood Neutrophil-Lymphocyte Ratio With Motor and Cognitive Function in Prodromal Parkinson's Disease.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Baseline peripheral inflammatory profiles predict phenoconversion in prodromal Parkinson's disease: a longitudinal cohort study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Association of Peripheral Blood Neutrophil-Lymphocyte Ratio With Motor and Cognitive Function in Prodromal Parkinson's Disease.Brain and behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionNeutrophil and lymphocyte levels and their ratio, the neutrophil-lymphocyte ratio (NLR), in the peripheral blood provide accessible indices of systemic inflammatory activity. In this study, we evaluated whether these blood markers are linked to motor symptoms and cognitive performance during the prodromal stage of Parkinson's disease (PD).
methodsWe analyzed data from the prodromal cohort of the Parkinson's Progression Markers Initiative, which included 1,269 individuals with prodromal PD features (isolated REM sleep behavior disorder [RBD]: n = 116, isolated hyposmia: n = 570, combined: n = 583) and 284 healthy controls. Motor impairment was measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale Part 3, while cognition was assessed through a broad neuropsychological test battery.
resultsCompared with controls, participants with prodromal PD had lower lymphocyte counts (p < 0.001) and higher NLR values (p = 0.008), whereas neutrophil counts did not differ between the groups (p = 0.749). No significant differences were observed across prodromal phenotypes for these markers. Correlation analysis demonstrated that NLR, but not neutrophil or lymphocyte counts alone, was associated with more severe motor impairment after false discovery rate correction (Q = 0.011). This relationship was evident in participants with both RBD and hyposmia and those with hyposmia only. However, the interaction between phenotype and NLR on motor severity was not significant. There were no significant associations of neutrophil or lymphocyte profiles with cognitive performance.
conclusionOur findings indicate that higher NLR, largely reflecting reduced lymphocyte levels, is already present in the prodromal phase of PD and relates to the severity of motor symptoms. Prospective longitudinal studies are needed to clarify whether NLR has predictive value for progression to overt PD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.