ReviewInternational journal of nanomedicine2025
Current Applications and Future Challenges of Mesenchymal Stem Cell-Extracellular Vesicles in Tissue Engineering: A Bibliometric Analysis.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Global research trends in the comorbidity of erectile dysfunction and premature ejaculation: a 20-year bibliometric analysis [2005-2025].Translational andrology and urology · 2026Article
- Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extracellular vesicles derived from mesenchymal stem cells (MSCs-EVs) are nano-sized vesicles and have become key mediators in tissue engineering and emerging therapeutic agents in regenerative medicine. This study systematically assessed the global research trend of MSCs-EVs for tissue engineering through bibliometric analysis of literature from 2014 to 2024. Methods: A comprehensive search of Web of Science retrieved 752 eligible articles. We visualized and further analyzed collaboration, co-citation, co-authorship and co-occurrence through VOSviewer and Citespace, focusing on their application and future development trends. Results: Annual publications increased continuously, with China and the United States accounting for 48.9% and 19.1% of research output, respectively, accompanied by intensive transnational cooperation. China leads in number of publications, number of years, total citations, H index and collaboration. The evolution of research trends confirms that the current field of application has expanded from cellular repair to drug delivery systems and biomaterial integration. Keyword cooccurrence reveals three clusters of research: artificial editing of exosomes (membranes), drug delivery (drugs, nucleic acids), and regeneration mechanisms (bone morphogenesis, angiogenesis regulation). The International Journal of Molecular Science became the most influential journal, and Shanghai Jiaotong University was a leader in institutional productivity. Conclusion: This study is the first comprehensive quantitative analysis of tissue-engineered EVs and details trends and advances in tissue-engineered EVs research within the field of regenerative medicine. It portrays recent frontiers and hotspots, providing valuable insights for researchers in this particular area of research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.