Evidence map›Paper›PMID 41409166›Full record

ArticleACS pharmacology & translational science2025

Asparaginase with Combined Mutations: Optimized Biochemistry and Lowered Allergic Risk.

Tales Costa-Silva, Grace V Ruiz-Lara, Iris Munhoz Costa, Adalberto Pessoa, Gisele Monteiro

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tales Costa-SilvaCenter for Natural and Human Sciences, Federal University of ABC, Santo André, São Paulo 09210580, Brazil.
Grace V Ruiz-LaraDepartment of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Science, University of São Paulo, São Paulo SP 05508-000, Brazil.
Iris Munhoz CostaDepartment of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Science, University of São Paulo, São Paulo SP 05508-000, Brazil.
Adalberto PessoaDepartment of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Science, University of São Paulo, São Paulo SP 05508-000, Brazil.
Gisele MonteiroCenter for Natural and Human Sciences, Federal University of ABC, Santo André, São Paulo 09210580, Brazil.ORCID https://orcid.org/0000-0002-3385-047X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotechnology and biomedical advances have driven the development of novel biopharmaceuticals to meet growing clinical demands. Among approved biologics, native

Indexed as

allergyALL-molecular biologyALL-molecular diagnosis and therapyasparaginasebiobetterbiologics

Identifiers

PMID41409166
PMCPMC12706811

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.