Evidence map›Paper›PMID 41409224›Full record

ArticleOpen forum infectious diseases2025

Estimation of General Practitioner Visits, Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus and Influenza Virus, and Costs Associated With Hospitalizations, in Older Adults in France From 2010 to 2020.

Charles Nuttens, Vanessa Barbet, Clélia Bignon-Favary, Emilie Lambourg, Stéphane Fiévez, Emmanuelle Blanc, Mathias Vacheret, Hervé Liliu, Philippe Vanhems, Jean-Sébastien Casalegno and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Charles NuttensMedical Affairs Vaccines, Pfizer, Paris, France.ORCID https://orcid.org/0000-0001-6288-8023
Vanessa BarbetHoriana, Bordeaux, France.ORCID https://orcid.org/0009-0001-2762-787X
Clélia Bignon-FavaryHoriana, Bordeaux, France.
Emilie LambourgHoriana, Bordeaux, France.ORCID https://orcid.org/0000-0003-2712-177X
Stéphane FiévezMedical Affairs Vaccines, Pfizer, Paris, France.ORCID https://orcid.org/0009-0009-8013-2399
Emmanuelle BlancMedical Affairs Vaccines, Pfizer, Paris, France.
Mathias VacheretMedical Affairs Vaccines, Pfizer, Paris, France.
Hervé LiliuInbeeo, London, UK.
Philippe VanhemsService Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, France.
Jean-Sébastien CasalegnoHospices Civils de Lyon, Hôpital de la Croix-Rousse, Centre de Biologie Nord, Institut des Agents Infectieux, Laboratoire de Virologie, Lyon, France.ORCID https://orcid.org/0000-0003-3271-9856
Laurence WatierEpidemiology and Modelling of Bacterial Escape to Antimicrobials, Institut Pasteur, Paris, France.ORCID https://orcid.org/0000-0002-4057-1102
Paul LoubetVBIC, INSERM U1047, Univ Montpellier, Service des Maladies Infectieuses et Tropicales, CHU Nîmes, Nîmes, France.ORCID https://orcid.org/0000-0002-1218-9432
Caihua LiangVaccines Evidence Generation, Pfizer, Collegeville, Pennsylvania, USA.
Elizabeth BegierMedical Affairs Vaccines, Pfizer, Dublin, Ireland.ORCID https://orcid.org/0000-0002-1287-5416
Magali LemaitreHoriana, Bordeaux, France.ORCID https://orcid.org/0000-0001-8441-1840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Respiratory syncytial virus (RSV) and influenza virus are leading causes of respiratory infections, causing substantial numbers of hospitalizations and deaths, particularly among vulnerable groups such as infants and older adults. While the burden of influenza virus infection is well-documented, the burden of RSV infection in the adult population is often underestimated due to diagnostic challenges and infrequent standard-of-care testing. This study aimed to estimate the incidence of general practitioner (GP) visits, hospitalizations, and deaths attributable to RSV and influenza virus infections in French adults aged ≥50 years, with a focus on ≥65 years, using a time-series model-based approach. In addition, costs associated with hospitalizations were calculated. Methods: Cyclic Poisson regression models and weekly data from French medical administrative databases and electronic medical records over ten epidemic seasons (2010-2020) were used to estimate incidences for RSV and influenza. The results were stratified by age group, diagnosis causes (respiratory and cardiorespiratory) and diagnosis type (primary and secondary). Average costs per hospitalization were calculated and multiplied by the number of hospitalizations estimated. Results: Among adults aged ≥65 years, we estimated RSV infection was responsible for 647 619 GP visits 24 319 hospitalizations, and 878 deaths per year. Incidence rates for GP visits for RSV were twice as large as for influenza; hospitalization rates were similar and mortality was lower. The mean annual cost of RSV-attributable hospitalizations was 105 million €, similar to influenza. Conclusions: This study highlighted the burden of RSV disease in the adult population in France is higher than previous reported. We envisage that this model-based approach will be instrumental in evaluating the impact of RSV vaccination campaigns.

Indexed as

FranceincidenceinfluenzaRSVtime-series modeling

Identifiers

PMID41409224
PMCPMC12705988

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.