ReviewDrug design, development and therapy2025
Drug Delivery Systems Targeting the Knee Microenvironment: A Prospective Strategy for Knee Osteoarthritis Treatment.
Review in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation.Genes · 2026Article
- Nanozyme-Mediated Joint Homeostasis Restoration: Emerging Strategies for Arthritis Therapy.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (KOA) is a degenerative condition of the joints marked by the gradual deterioration of cartilage, inflammation, and pain, impacting millions globally. Treatment approaches for KOA encompass both surgical and non-surgical methods aimed at alleviating symptoms and enhancing functionality rather than providing a cure. Recent research into the mechanisms of osteoarthritis (OA) has highlighted the significance of the knee joint's microenvironment in the success of drug delivery, particularly with intra-articular therapies. A notable approach involves intra-articular (IA) injections, which allow for the targeted administration of medications directly into the joint area. Nevertheless, traditional treatments often fall short in effectiveness due to the limited bioavailability of drugs within the joint, quick clearance rates, and potential systemic side effects. Consequently, innovative drug delivery systems (DDS) that focus on the knee joint's microenvironment have emerged as a viable method to enhance treatment efficacy and improve patient outcomes. Additionally, drug delivery systems utilizing nanotechnology have shown advantages such as precise targeting, minimized systemic toxicity, and extended therapeutic effects in treating diseases. Gaining insight into these interactions is crucial for developing optimized drug delivery systems that can improve treatment results for individuals with knee disorders. This article examines the latest developments in nanotechnology-based therapies for KOA and explores future directions for enhancing and refining treatment strategies for this condition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.