Evidence map›Paper›PMID 41410751›Full record

ArticleCancer immunology, immunotherapy : CII2025

Spatial patterns and prognostic relevance of CD1a

Sergii Pavlov, Esraa Ali, Wenjing Ye, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Ondřej Daum, Václav Liška, Kari Hemminki, Andriy Trailin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sergii PavlovLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic. sergii.pavlov@lfp.cuni.cz.
Esraa AliLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Wenjing YeLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Lenka ČervenkováLaboratory of Cancer Treatment and Tissue Regeneration, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Filip AmbrozkiewiczLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Ondřej VyčítalLaboratory of Cancer Treatment and Tissue Regeneration, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Ondřej DaumLaboratory of Cancer Treatment and Tissue Regeneration, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Václav LiškaLaboratory of Cancer Treatment and Tissue Regeneration, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Kari HemminkiLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.
Andriy TrailinLaboratory of Translational Cancer Genomics, Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Alej Svobody 1665/76, 32300, Pilsen, Czech Republic.

Funding

AZV NU21-03-00506
6 · The paper itself

Abstract

The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired liver metastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a PATIENTS AND

methodsThis retrospective cohort included patients undergoing resection of primary CRC (pCRC) and synchronous LM (N = 55) or metachronous LM (N = 44). Immunohistochemical staining for CD1a and CD208 was performed on non-tumor adjacent mucosa (NAM), as well as tumor center (TC), inner margin (IM), outer margin (OM), and peritumoral zone (PT) of both pCRC and LM. Cell densities were quantified on whole-slide images using QuPath software and correlated with overall survival (OS).

resultsCD1a

conclusionThis study provides the first detailed mapping of CD1a

Indexed as

Antigens, CDAntigens, CD1Colorectal NeoplasmsDendritic CellsLectins, C-TypeLiver NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMembrane GlycoproteinsMiddle AgedMucous MembranePrognosisAntigens, CDAntigens, CD1CD1a antigenCLEC4C protein, humanLectins, C-TypeMembrane GlycoproteinsReceptors, ImmunologicImmature and mature dendritic cellsOverall survivalPrimary colorectal cancerSpatial immune profilingSynchronous and metachronous liver metastases

Identifiers

PMID41410751
PMCPMC12714677

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.