ArticleCardiology and therapy2026
Functionally Limiting Symptoms and Inability to Independently Complete Daily Activities Increase the Burden Felt by Caregivers to Patients with ATTR-CM.
Article in Cardiology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Burden of Transthyretin Amyloid Cardiomyopathy on Caregivers and Patients in Japan: A Cross‑Sectional Real‑World Survey.Advances in therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Burden of Disease survey characterized the humanistic burden of transthyretin amyloid cardiomyopathy (ATTR-CM) in 208 international patients not receiving disease-modifying therapy and their primary caregivers.
methodsPost hoc univariate analyses evaluated the relationships between patients' current symptoms and ability to complete activities of daily living (ADLs) with their caregivers' Zarit Burden Interview (ZBI), Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue, and Hospital Anxiety and Depression Survey Anxiety (HADS-A) and Depression (HADS-D) subscale scores.
resultsMost patients had wild-type ATTR-CM (91%; n = 141/155) and a New York Heart Association functional classification of I/II (78%; n = 156/199). Caregivers (n = 208) were a median age of 68 years, 85% were female, and 66% lived with the patient. Current patient symptoms of paralysis, heart failure, weakness (especially in the legs), leg pain, leg and ankle swelling, loss of sensation in the legs/arms, fatigue, insomnia, and weight loss were associated with a significantly (P < 0.05) higher caregiver ZBI score. Many of these symptoms were also associated with significantly (P < 0.05) higher PROMIS Fatigue and HADS-A scores; heart failure and weakness (especially in the legs) were associated with a significantly (P < 0.05) higher HADS-D score. Inability of patients to independently clean, bathe, cook, get in/out of bed, or walk were associated with significantly (P < 0.05) higher caregiver ZBI and HADS-D scores. Inability to independently clean and walk were associated with significantly (P < 0.05) higher PROMIS Fatigue and HADS-A scores.
conclusionsBurden is higher in caregivers of patients with ATTR-CM who have specific symptoms (including those causing disability) or an inability to independently complete ADLs. Graphical Abstract available for this article.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.