Evidence map›Paper›PMID 41411147›Full record

ReviewBlood2026

Posttransplant cyclophosphamide in HLA-matched peripheral blood transplantation: what's next?

David J Curtis, Geoffrey R Hill

Abstract readReview
In one paragraph

Review in Blood, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David J CurtisClinical Haematology, Alfred Health, Melbourne, Australia.ORCID 0000-0001-9497-0996
Geoffrey R HillTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
Preventing GVHD by inhibition of alloantigen presentation in the gutR01HL148164 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Geoffrey Roger HILL, Motoko Koyama · 2019 to 2026
$6.5M
Defining Protective CMV Immunity after TransplantationR01AI175535 · NIAID · FRED HUTCHINSON CANCER CENTER · PI Geoffrey Roger HILL · 2023 to 2026
$3.0M
NCI NIH HHS P01 CA018029NCI NIH HHS P01 CA078902NHLBI NIH HHS R01 HL148164NIAID NIH HHS R01 AI175535
6 · The paper itself

Abstract

abstractThe use of posttransplant cyclophosphamide was initially pioneered as a means of permitting haploidentical transplantation across HLA barriers. This approach has now become a standard of care for the prevention of significant acute and chronic graft-versus-host disease (GVHD) after related and unrelated HLA-matched allogeneic peripheral blood stem cell transplant across a full spectrum of conditioning intensities. This article discusses recent advances, the mechanisms of action, and important unresolved questions in the prevention of GVHD that will help inform new prospective clinical studies.

Indexed as

CyclophosphamideGraft vs Host DiseaseHLA AntigensImmunosuppressive AgentsPeripheral Blood Stem Cell TransplantationHistocompatibility TestingHumansTransplantation ConditioningCyclophosphamideHLA AntigensImmunosuppressive Agents

Identifiers

PMID41411147
PMCPMC12983030

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.