ArticlePloS one2025
Early skeletal muscle loss and clinical outcomes in critically ill patients in the medical intensive care unit: A retrospective cohort study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute skeletal muscle wasting is a common complication among critically ill patients and contributes to prolonged stays in the intensive care unit (ICU) and poor outcomes. Although bedside ultrasound of the rectus femoris cross-sectional area (RFcsa) is useful for assessing muscle loss, data on its incidence and predictors in medical ICU populations are limited. Our study aimed to determine the incidence of significant muscle wasting (≥10% reduction in RFcsa) and to identify modifiable predictors, particularly early rehabilitation.
methodsThis retrospective cohort study was conducted at a tertiary academic hospital in South Korea. Seventy-six adult ICU patients who underwent serial ultrasound assessments of RFcsa within 48 h of admission and again on day 7 were included. Patients were categorized based on whether they experienced a ≥ 10% reduction in RFcsa. Clinical characteristics, interventions, and outcomes were compared between groups. Multivariate logistic regression identified predictors of significant muscle loss, ICU mortality, and in-hospital mortality.
resultsA significant reduction in RFcsa (≥10%) was observed in 53.9% of patients (n = 41/76). These patients had longer ICU stays (median 15.0 vs. 10.0 d, p = 0.001) and were less likely to receive Level 3 or higher ICU-level rehabilitation (4.9% vs. 20.0%, p = 0.042). Multivariate analysis revealed that Level 3 or higher rehabilitation was independently associated with reduced muscle wasting (OR: 0.183; 95% CI: 0.035-0.970; p = 0.046). Multivariable analyses revealed that increased total bilirubin and decreased albumin levels were associated with ICU mortality. In-hospital mortality, however, was independently associated with a higher Charlson comorbidity index, elevated bilirubin and C-reactive protein levels, and low albumin. A decrease in RFcsa of at least 10% was not significantly associated with either outcome.
conclusionsMore than half of the patients in the ICU experienced significant muscle loss within the first week of being admitted. Receiving structured rehabilitation at Level 3 or higher was independently associated with reduced muscle wasting. This suggests that early mobilization strategies may help preserve muscle mass in critically ill patients.
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