Evidence map›Paper›PMID 41411649›Full record

ArticleJMIR aging2025

A Hybrid Rule- and Large Language Model-Based Embodied Voice Assistant (GRACE) for Cognitive Stimulation in Older Adults: Usability Study Assessing Technical Feasibility, Technology Acceptance, and Working Alliance.

Rasita Vinay, Ekaterina Uetova, Nora Camilla Tommila, Nikola Biller-Andorno, Tobias Kowatsch

Abstract read
In one paragraph

Article in JMIR aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cognitive Reablement Using Digital Voice Assistants for People Living With Dementia or Mild Cognitive Impairment: A Co-Design Study.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rasita VinayInstitute of Biomedical Ethics and History of Medicine, Faculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-0490-5697
Ekaterina UetovaSchool of Computer Science, Technological University Dublin, Dublin, Ireland.ORCID https://orcid.org/0009-0009-9605-9616
Nora Camilla TommilaDepartment of Management, Technology, and Economics, ETH Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0002-8926-7184
Nikola Biller-AndornoInstitute of Biomedical Ethics and History of Medicine, Faculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-7661-1324
Tobias KowatschDepartment of Management, Technology, and Economics, ETH Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-5939-4145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe health and economic burden of dementia has led the World Health Organization to recognize it as a public health priority. Although there currently does not exist a cure for dementia, there are multiple interventions aimed at preventing the risk of dementia and improving the quality of life of people with dementia. Voice assistants (VAs), particularly those using large language models (LLMs), have emerged as promising tools to deliver these interventions to older adults due to their accessible and natural interface.

objectiveThis pilot study aimed to evaluate the technical feasibility (ie, functional performance and usability) and user acceptance of the embodied rule-based and LLM VA GRACE, as well as the perceived strength of the collaborative relationship or working alliance, between GRACE and healthy older adults during the delivery of cognitive stimulation interventions.

methodsA pilot study was conducted with 21 healthy German-speaking adults aged 60 years and older. Participants interacted with GRACE in a laboratory setting for 10-15 minutes. The interaction involved a structured cognitive stimulation session using rule-based and LLM components. Data were collected using pre- and postinteraction questionnaires and semistructured interviews. Quantitative analysis included descriptive statistics and Wilcoxon signed rank tests. Qualitative data were analyzed thematically.

resultsParticipants rated GRACE positively, with statistically significant scores above neutral (P<.001 for perceived ease of use, usefulness, enjoyment, and working alliance; P=.009 for perceived control; and P=.009 for intention to continue interacting). Thematic analysis revealed that GRACE was perceived as easy to understand and unambiguous, friendly, and supportive, with intervention components viewed as enjoyable and appropriately challenging. Areas for improvement included personalization, response delays, and voice quality.

conclusionsThe results suggest that embodied rule-based and LLM VAs like GRACE are feasible and well-received tools for delivering cognitive interventions to older adults. Future iterations will incorporate feedback and extend testing to individuals at risk for dementia.

Indexed as

DementiaAgedAged, 80 and overFeasibility StudiesFemaleHumansLanguageLarge Language ModelsMaleMiddle AgedPilot ProjectsQuality of LifeSurveys and Questionnairescognitive interventiondementiadigital health interventionsembodied conversational agenthuman-computer interactionlarge language modelolder adultsvoice assistant

Identifiers

PMID41411649
PMCPMC12757713

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.