Evidence map›Paper›PMID 41412908›Full record

Trial reportEuropean urology2026

[

Ashesh B Jani, Vishal R Dhere, Subir Goyal, Eduard Schreibmann, Pretesh R Patel, Bruce Hershatter, Joseph W Shelton, Sheela Hanasoge, Nikhil T Sebastian, Sagar A Patel and 11 more

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ashesh B JaniDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA. Electronic address: abjani@emory.edu.
Vishal R DhereDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Subir GoyalBiostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Eduard SchreibmannDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Pretesh R PatelDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Bruce HershatterDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Joseph W SheltonDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Sheela HanasogeDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Nikhil T SebastianDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Sagar A PatelDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Raghuveer HalkarDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Sherrie CooperDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Bridget FielderDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Olayinka A Abiodun-OjoDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Ismaheel LawalDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Aliza MushtaqDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Viraj A MasterDepartment of Urology, Emory University, Atlanta, GA, USA.
Shreyas S JoshiDepartment of Urology, Emory University, Atlanta, GA, USA.
Omer KucukDepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Mehmet A BilenDepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
David M SchusterDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
Advanced PET-CT Directed Post-Prostatectomy Radiotherapy to Enhance Prostate Cancer OutcomesR01CA226992 · NCI · EMORY UNIVERSITY · PI JANI, ASHESH, SCHUSTER, DAVID MICHAEL · 2019 to 2023
$3.1M
NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA226992
6 · The paper itself

Abstract

BACKGROUND AND

objectiveIn EMPIRE-1, [

methodsEMPIRE-2 was a randomized trial of [ KEY FINDINGS AND LIMITATIONS: In the cohort of 140 patients, 59 randomized to arm 1 patients and 60 randomized to arm 2 completed RT. Median follow-up was 2.6 yr (interquartile range 1.8-4.0). The 2-yr EFS rates were 87% for the overall EMPIRE-2 cohort versus 80% for the EMPIRE-1 comparison cohort (difference 7.7%, 95% confidence interval [CI] 4.7-12%; p = 0.01). After propensity score weighting, the corresponding 2-yr EFS rates were 84% versus 73% (difference 11%, 95% CI 3.6-24%; p = 0.01). The 2-yr EFS rates in the EMPIRE-2 study arms were 87% for [ CONCLUSIONS AND CLINICAL IMPLICATIONS: Use of either [

Indexed as

Carboxylic AcidsCyclobutanesGallium RadioisotopesMolecular ImagingNeoplasm Recurrence, LocalPositron-Emission TomographyProstatectomyProstatic NeoplasmsRadiopharmaceuticalsSalvage TherapyAgedGallium IsotopesHumansMaleMiddle AgedRadiotherapy DosageCarboxylic AcidsCyclobutanesfluciclovine F-18gallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesPSMA-11RadiopharmaceuticalsFluciclovineMolecular imagingProstate cancerProstate-specific membrane antigenRadiotherapyRandomized controlled trial

Identifiers

PMID41412908
PMCPMC12879884

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.