Evidence map›Paper›PMID 41413324›Full record

ArticleBiomolecular NMR assignments2025

Mary E Cook, Kristen M Varney, Xinhao Zhuang, Aysenur Torun Yazici, Filippo Mancia, David J Weber

Abstract read
In one paragraph

Article in Biomolecular NMR assignments, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mary E CookDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD, 21201, USA.
Kristen M VarneyDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD, 21201, USA.
Xinhao ZhuangThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD, 21201, USA.
Aysenur Torun YaziciIrving Medical Center, Columbia University, New York, NY, 10032, USA.
Filippo ManciaIrving Medical Center, Columbia University, New York, NY, 10032, USA.
David J WeberDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD, 21201, USA. DWeber@som.umaryland.edu.

Funding

Structural basis of receptor-mediated cellular vitamin A uptakeR01EY027405 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI George Khelashvili, Filippo Mancia · 2017 to 2026
$4.4M
Signal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3M
National Institutes of Health, United States R01EY027405National Institutes of Health, United States R01GM129327NEI NIH HHS R01 EY027405NIGMS NIH HHS R01 GM129327
6 · The paper itself

Abstract

Vitamin A is essential for vision and many other biological processes required for human health and survival. Extracellular retinol binding protein (RBP) delivers vitamin A into the cell upon binding to the vitamin A transporter, STRA6. However, when retinol free RBP binds to STRA6, it induces vitamin A transport out of the cell. The bi-directionality of vitamin A transport is thought to be regulated further by an intracellular protein-protein interaction (PPI) between STRA6 and the EF-hand Ca

Indexed as

CalciumCalmodulinMembrane ProteinsNuclear Magnetic Resonance, BiomolecularAmino Acid SequenceAnimalsNitrogen IsotopesProtein BindingSheepCalciumCalmodulinMembrane ProteinsNitrogen-15Nitrogen IsotopesCalcium-bindingEF-handRetinol-binding protein, calmodulinSTRA6Vitamin a transporter

Identifiers

PMID41413324
PMCPMC12714816

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.