ReviewThyroid research2025
Coffee consumption and risk of thyroid cancer: a systematic review and meta-analysis of cohort and case control studies.
Review in Thyroid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Coffee and Caffeine Intake and Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Cohort Studies.Health science reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe risk of thyroid cancer (TC) has been steadily increasing globally, prompting interest in identifying modifiable risk factors. Coffee, rich in bioactive compounds with potential metabolic effects, may influence TC risk, yet the relationship remains unclear. Therefore, this study aims to systematically review and conduct a meta-analysis of observational studies to assess the association between coffee consumption and the risk of TC.
methodsComprehensive searches were conducted in major databases through September 2025 to identify appropriate studies. Following the study selection process, relevant data were extracted. Pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CIs) were calculated using random-effects models to account for heterogeneity.
resultsThis meta-analysis of 10 observational (cohort and case-control) studies found no statistically significant association between coffee consumption and TC risk across both study designs. The pooled analysis of four cohort studies (6 effect sizes) yielded a pooled HR of 0.94 (95% CI: [0.74, 1.20], p = 0.645; I² = 31%), indicating no meaningful risk reduction. The pooled analysis of six case-control studies (8 effect sizes) showed a non-significant trend toward a protective effect, with a pooled OR of 0.78 (95% CI: [0.59, 1.03], p = 0.091; I² = 12%), indicating low heterogeneity across the designs.
conclusionsOverall, the findings suggest that coffee consumption is not significantly associated with an increased risk of TC. Case-control studies indicate a possible protective trend that warrants further investigation, and the low heterogeneity supports the consistency of these results. Nonetheless, additional large-scale prospective studies are needed to confirm these findings and clarify the underlying biological mechanisms. CLINICAL TRIAL NUMBER: Not applicable.
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