ReviewStem cell research & therapy2025
Comparative β-cell development: insights from Rodents, humans and induced pluripotent stem cell models.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Stepwise pancreatic β-cell differentiation protocols, designed to recapitulate key developmental milestones of pancreatic organogenesis-from definitive endoderm to mature, glucose-responsive β-cells-draw on insights from both rodent and human developmental biology. These protocols consist of three critical stages: the formation of definitive endoderm, the induction of pancreatic progenitors, and the maturation of functional β-cells. Here, we discuss human and rodent embryonic development together with stem-cell differentiation protocols in concert to identify gaps and bottlenecks that limit the practicality and scalability of current protocols. Ultimately, the aim of refining these processes is to produce functional β-cells from pluripotent stem cells to treat, and potentially cure, diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.