Evidence map›Paper›PMID 41413626›Full record

ArticleScientific reports2025

Genetic variation of cutaneous leishmaniasis causative species in Ethiopia.

Selfu Girma, Mesfin Tafesse Gemeda, Adugna Abdi Woldesemayat, Dawit Hailu Alemayehu, Abaysew Ayele, Semira Eshetu, Feleke Tilahun Zewdu, Eshetu Molla, Tizita Yosef, Shimelis Nigussie and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Selfu GirmaArmauer Hansen Research Institute, Addis Ababa, Ethiopia. selfugirma2@gmail.com.
Mesfin Tafesse GemedaBiotechnology and Bioprocess Centre of Excellence, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia. mesfin.tafesse@aastu.edu.et.
Adugna Abdi WoldesemayatBiotechnology and Bioprocess Centre of Excellence, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia.
Dawit Hailu AlemayehuArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Abaysew AyeleArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Semira EshetuALERT Comprehensive Specialized Hospital, Dermatology Unit, Addis Ababa, Ethiopia.
Feleke Tilahun ZewduBoru Meda General Hospital, Amhara Regional state, Dessie, Ethiopia.
Eshetu MollaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Tizita YosefSchool of Medicine, Department of Dermatology and Venerology, Addis Ababa University College of Health Science, Addis Ababa, Ethiopia.
Shimelis NigussieALERT Comprehensive Specialized Hospital, Dermatology Unit, Addis Ababa, Ethiopia.
Molalegne BitewBio and Emerging Technology Institute, Addis Ababa, Ethiopia.
Kidist BoboshaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Endalamaw GadisaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Ethiopia, three Leishmania species are linked to Cutaneous Leishmaniasis (CL): Leishmania aethiopica, L. tropica, and L. donovani. Among these, L. aethiopica is the most commonly reported cause. The clinical presentations of CL are broadly classified into localized (LCL), mucocutaneous (MCL), and diffuse cutaneous CL (DCL) forms. There is limited data on the genetics of these pathogens, despite the different clinical forms and estimated 50 thousand new cases of CL per year. In this research, we sequenced the ITS1 region from 72 clinical specimens. In the in-silico PCR-RFLP, 67 were identified as L. aethiopica (93.1%), and 5 were identified as L. tropica (6.9%). In the ITS1 sequence analysis, among the isolates with L. aethiopica PCR-RFLP pattern, 13.4% (n = 9) were found to be putative hybrids between L. donovani and L. aethiopica. We recommend a powered study to explore the public health implication of the different species, and interspecies hybrids.

Indexed as

DNA, ProtozoanLeishmaniaLeishmaniasis, CutaneousAdolescentAdultEthiopiaFemaleGenetic VariationHumansMaleMiddle AgedPhylogenySpecies SpecificityYoung AdultDNA, ProtozoanClinical presentationCutaneous leishmaniasisHybrid strainsITS1 targeted sequencingLeishmania aethiopicaMolecular epidemiology

Identifiers

PMID41413626
PMCPMC12714746

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.