Evidence map›Paper›PMID 41413686›Full record

ReviewExperimental & molecular medicine2025

EGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting.

Giulio Verna, Valentina Fantini, Alessandra Grieco, Alessia Ciarrocchi, Valentina Sancisi

Abstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giulio VernaLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Valentina FantiniLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.ORCID http://orcid.org/0000-0003-1244-4453
Alessandra GriecoLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Alessia CiarrocchiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Valentina SancisiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy. valentina.sancisi@ausl.re.it.ORCID http://orcid.org/0000-0003-4357-1228

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG26377Fondazione Umberto Veronesi (Umberto Veronesi Foundation) Fellowship 2025Ministero della Salute (Ministry of Health, Italy) Ricerca Corrente Annual Pro-gram 2025
6 · The paper itself

Abstract

The tumor microenvironment (TME) is often hypoxic. EGLN1, which encodes the oxygen sensor PHD2, plays a crucial role not only in the survival of cancer cells but also in regulating other cell types that reside in the TME. In this Review, we explore the role of this protein in some of the key components of the TME, focusing on the functions of EGLN1/PHD2 in endothelial, stromal and immune cells. So far, the activity of EGLN1/PHD2 has been characterized in different cell types, albeit with controversial outcomes in different cancer settings. This Review aims to discuss the role of EGLN1/PHD2 in the TME and the strategies targeting this protein that might be used to hit tumors.

Indexed as

Hypoxia-Inducible Factor-Proline DioxygenasesNeoplasmsTumor MicroenvironmentAnimalsHumansMolecular Targeted TherapyEGLN1 protein, humanHypoxia-Inducible Factor-Proline Dioxygenases

Identifiers

PMID41413686
PMCPMC12800280

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.