Evidence map›Paper›PMID 41413871›Full record

ArticleBMC cancer2025

EHF as a key regulator mediating cell migration and may contribute to tumor immune infiltration and progression in human endometrial cancer.

Xinyi Chen, Xudong Chen, Ling Yuan, Tangli Kan, Xiaoyi Ding, Yi You, Zhou Liu, Xiaoqing Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinyi Chen *Department of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Xudong Chen *Department of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Ling YuanDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Tangli KanDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Xiaoyi DingDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Yi YouDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China.
Zhou LiuDepartment of Gynecology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China.
Xiaoqing YangDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University, School of Medicine, Nantong University, No.20 Xisi Road, Nantong, Jiangsu Province, 226001, China. ntyxq169@126.com.

Funding

Jiangsu Provincial Research Hospital YJXYY202204-2-YSB04Key Discipline Group of Obstetrics and Gynecology PWZxq2022-15Natural Science Foundation of Nantong Science and Technology Plan JC 2023086the third-level talent of the Seventh Phase of the 333 Talent Program in Jiangsu Province No. 2022-3-29-061
6 · The paper itself

Abstract

introductionIt is crucial to identify effective molecular markers for early endometrial cancer (EC) detection and therapeutic targets for late-stage EC. However, the role of E26 transformation-specific homologous factor (EHF) in EC remains poorly characterized. MATERIALS AND

methodsPublic databases were utilized to investigate the molecular features of EHF and its significance in the pathogenesis of EC. Analyses including single - gene correlation, functional enrichment, and immune infiltration were conducted. We used lentiviral-mediated EHF silencing in HEC-1B cells to examine EHF's impact on cell cycle, immigration, invasion, and proliferation.

resultsHigh EHF expression was linked to a more dismal prognosis of EC. The degree of tumor invasion, histologic type and stage, and clinical stage were significantly associated with EHF overexpression. Functional enrichment research conclusively indicated that EHF was closely linked to various activities, including the cell cycle, metabolic pathways, and interleukin 17 signaling pathway. The expression of EHF exhibited a negative connection with the presence of dendritic cells, natural killer (NK) cells, CD4 + type 1 T-helper cells, and the varying infiltration levels of other immune cells. In vitro study revealed increased EHF levels in endothelial cell tissues and cell lines. Analyses of functional components showed that EHF greatly enhances EC cell migration and development.

conclusionElevated EHF expression in EC patients correlated with diminished immune cell infiltration and a worse outcome. Decreasing EHF levels also affected the invasion and proliferation of EC cells. These findings highlight EHF as a putative prognostic and diagnostic biomarker for EC.

Indexed as

Cell MovementDNA-Binding ProteinsEndometrial NeoplasmsLymphocytes, Tumor-InfiltratingBiomarkers, TumorCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPrognosisBiomarkers, TumorDNA-Binding ProteinsEHFImmune cell infiltrationInvasionPrognosisProliferation

Identifiers

PMID41413871
PMCPMC12882267

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.