Evidence map›Paper›PMID 41414646›Full record

ArticleAdvanced healthcare materials2026

Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction.

Joshua M Mesfin, Alexander Chen, Quincy P Lyons, Michael B Nguyen, Maria L Karkanitsa, Justin Yu, Van K Ninh, Emily Gardner, Elyse G Wong, Sriya N Paleti and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Joshua M MesfinShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-1022-8175
Alexander ChenSanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, USA.
Quincy P LyonsShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0003-1042-5627
Michael B NguyenShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Maria L KarkanitsaShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-3474-2371
Justin YuShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Van K NinhShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-6017-4035
Emily GardnerShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Elyse G WongShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Sriya N PaletiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Julian ChengShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Benjamin D BridgelalShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0007-8986-5201
Kate E ReimoldShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0006-5353-4614
Selena CaoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Connor UhreShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Colin G LuoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Zhenxing FuShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Kevin R KingShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-1472-2189
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-6179-898X

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Infusible Extracellular Matrix for Treating Myocardial InfarctionR01HL165232 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L · 2022 to 2025
$2.9M
Elucidating Cell Communication Networks during Tissue Inflammation, Fibrosis, and RegenerationDP2AR075321 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KING, KEVIN R · 2018 to 2018
$2.4M
Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and DiseaseT32HL160507 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Andrew D. McCulloch · 2022 to 2026
$1.6M
Biological Mechanisms of the Infarct BorderzoneR01HL181539 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin R King · 2025 to 2026
$1.5M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
American Heart Association post-doctoral fellowship 24POST1242447American Heart Association pre-doctoral fellowship 23PRE1023221American Heart Association pre-doctoral fellowship 24PRE1180449National Institutes of Health National Heart, Lung, and Blood Institute R01HL165232National Institutes of Health National Heart, Lung, and Blood Institute R01HL181539National Institutes of Health SIG #S10 OD026929NHLBI NIH HHS R01 HL165232NHLBI NIH HHS R01 HL181539NHLBI NIH HHS T32 HL007444NHLBI NIH HHS T32 HL105373NHLBI NIH HHS T32 HL160507NIAMS NIH HHS DP2 AR075321NIBIB NIH HHS T32 EB009380NIH HHS S10 OD026929NIH HHS T32HL007444NIH HHS T32HL105373NIH HHS T32HL160507NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) DP2AR075321NIH, NIBIB Training T32EB009380NINDS NIH HHS P30 NS047101NSF GRFP
6 · The paper itself

Abstract

To mitigate the pathological effects of myocardial infarction, we developed and investigated a pro-reparative decellularized extracellular matrix (ECM) biomaterial, an intravascularly infusible ECM (iECM). However, the cellular and molecular mechanisms by which iECM mediates repair are unknown because investigations have relied on bulk techniques. Here, we leverage single-nucleus RNA sequencing (snRNAseq) to measure pro-repair responses in various cell types across acute timepoints (1, 3, and 7 days post infusion). In iECM, we found pro-reparative macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis. These findings are validated through spatial transcriptomics. Thus, we define the pro-reparative nature of the decellularized ECM biomaterial on cardiac cell types and elucidate previously undiscovered therapeutic pathways, further demonstrating the potential of iECM as an MI therapy, as well as display the wealth of data generated from next-generation sequencing.

Indexed as

Biocompatible MaterialsDecellularized Extracellular MatrixExtracellular MatrixMyocardial InfarctionAnimalsHumansMiceBiocompatible MaterialsDecellularized Extracellular Matrixbiomaterialdecellularized extracellular matrixinfusiblemyocardial infarctionsnRNAseqtherapeutic

Identifiers

PMID41414646
PMCPMC13378492

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.