Trial reportCNS neuroscience & therapeutics2025
Multi-Site Theta-tACS Improves Memory and Language Performance and Associated Local and Remote Functional Connectivity in Mild Cognitive Impairment.
Trial report in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multi-Site Theta-tACS Improves Memory and Language Performance and Associated Local and Remote Functional Connectivity in Mild Cognitive Impairment.CNS neuroscience & therapeutics · 2025Trial
- Precision non-invasive transcranial electromagnetic stimulation: a thematic review of optimizing spatial, temporal, and dose dimensions.European archives of psychiatry and clinical neuroscience · 2026Review
- The role of stem cells and their engineering strategies in the repair of nerve damage in intracerebral hemorrhage.Cell & bioscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundWhile multi-site noninvasive brain stimulation demonstrates enhanced cognitive benefits in mild cognitive impairment (MCI), the efficacy of transcranial alternating current stimulation (tACS) in this paradigm remains unestablished. The study aims were to investigate the therapeutic effects of multi-site tACS on MCI patients and its underlying neural mechanism.
methodsA parallel, sham-controlled trial was conducted with 60 MCI participants assigned to multi-site tACS (prefrontal gyrus and precuneus), single-site tACS (precuneus), or sham groups. All participants underwent 20 days of 7 Hz tACS concurrent with working memory training. Cognitive assessments and fMRI examinations were performed pre- and post- intervention. Local and remote functional connectivity changes were evaluated using regional homogeneity (Reho) and resting-state network (RSN) analyses, respectively.
resultsMulti-site tACS demonstrated superior cognitive improvements, particularly in verbal fluency (p = 0.006) and recognition memory (p = 0.025), compared to sham stimulation. Significant ReHo changes were observed in the superior frontal gyrus (SFG) and superior temporal gyrus (STG) exclusively in the multi-site group (p < 0.05). Additionally, multi-site tACS induced broader functional connectivity alterations in the default mode network (DMN), executive control network (ECN), and left frontoparietal network (FPN). Correlations were found between the Reho changes in SFG and STG and the score changes of immediate memory (r = 0.367, p = 0.039) and language naming (r = 0.371, p = 0.037), respectively. Functional connectivity changes in the right inferior parietal lobe were also significantly correlated with the score changes of language naming (r = -0.374, p = 0.035). Moreover, more functional connectivity changes between the prefrontal gyrus stimulation site and the salience network and DMN were also detected in the multi-site group relative to the single-site group.
conclusionsMulti-site tACS is more effective than single-site tACS in enhancing cognitive functions and modulating cognition-related brain networks in MCI patients. These superior neuromodulatory effects of multi-site tACS may be attributed to its capacity to modulate functional networks across the prefrontal gyrus more extensively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.