ArticleKorean journal of clinical oncology2025
The relationship between ovarian and colorectal cancers: a systematic review and meta-analysis.
Article in Korean journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis systematic review and meta-analysis aimed to examine the relationship between ovarian and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).
methodsA comprehensive search was conducted across multiple databases, including Scopus, Web of Science, PubMed, and Google Scholar. A total of 20 studies were included in the final analysis.
resultsThe results indicated that women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR, 1.69; 95% confidence interval [CI], 1.39-1.98), with an increased risk for both colon (SIR, 1.57; 95% CI, 1.14-1.99) and rectal cancers (SIR, 1.58; 95% CI, 1.38-1.78). Subgroup analysis of borderline ovarian tumor revealed an SIR for colorectal cancer of 1.27 (95% CI, 0.99-1.55), with a significant risk in the serous subtype (SIR, 1.38; 95% CI, 1.09-1.67). Conversely, studies examining ovarian cancer in women diagnosed with colorectal cancer showed an SIR of 1.48 (95% CI, 1.17-1.79). Specifically, women with colon cancer had a higher incidence of ovarian cancer (SIR, 1.64; 95% CI, 1.25-2.03), while women with rectal cancer showed a decreased risk (SIR, 0.88; 95% CI, 0.77-0.99). The results underscore the potential bidirectional relationship between ovarian and colorectal cancers, which may be influenced by genetic predispositions.
conclusionFuture advanced genetic studies are needed to better understand the underlying molecular mechanisms. Additionally, the results emphasize the importance of careful cancer surveillance and early detection strategies for women with a history of either ovarian cancer or colorectal cancer.
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