ArticleClinical journal of the American Society of Nephrology : CJASN2026
Incident Pulmonary Hypertension and Its Risk Factors in CKD.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
key pointsLower eGFR and higher B-type natriuretic peptide are associated with increased odds of developing pulmonary hypertension. Albuminuria was not associated with the development of incident pulmonary hypertension.
backgroundPulmonary hypertension (PH) is a common comorbid condition in patients with CKD and is associated with high mortality. We sought to identify the incidence of PH and the relation of kidney function and volume status to its development in a large cohort of patients with CKD.
methodsThe study sample included 1076 participants from the Chronic Renal Insufficiency Cohort Study with two or more measurements of tricuspid regurgitation velocity by transthoracic echocardiography. Incident PH was defined as a tricuspid regurgitation velocity of ≥2.8 m/s (reflecting a right ventricular systolic pressure gradient ≥31 mm Hg). Multivariable logistic regression adjusting for demographics, comorbid conditions, and medications was used to evaluate the relation of kidney function (eGFR and albuminuria) as well as B-type natriuretic peptide (BNP) to incident PH.
resultsOver a median of 3.0 years, 120 patients developed incident PH (incidence rate 2.70 cases per 100 person-years). Each 10 ml/min per 1.73 m 2 lower eGFR was associated with 29% (odds ratio, 1.29; 95% confidence interval, 1.10 to 1.52) higher odds of the development of PH after adjustment for confounders, while each doubling of BNP was associated with a 32% (odds ratio, 1.32; 95% confidence interval, 1.15 to 1.51) higher odds. There was no significant relation between urine albumin excretion and incident PH.
conclusionseGFR and BNP were independently associated with the development of incident PH. Closer attention to these potentially modifiable risk factors is warranted to slow the progression of this common comorbidity of patients with CKD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.