Evidence map›Paper›PMID 41415375›Full record

ArticlebioRxiv : the preprint server for biology2025

High-throughput

Jiangshan Bai, Qingji Lyu, Jimin Tan, Robbyn Issner, Bailey Tischer, Hanqing Liu, Viraat Goel, Xinyu Ling, Bradley E Bernstein, Aristotelis Tsirigos and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiangshan BaiGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Qingji LyuGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Jimin TanGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Robbyn IssnerGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Bailey TischerGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Hanqing LiuGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Viraat GoelGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Xinyu LingGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Bradley E BernsteinGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.
Aristotelis TsirigosDepartment of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-7512-8477
Anders S HansenGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.ORCID 0000-0001-7540-7858
Bo XiaGene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.ORCID 0000-0003-0929-7253

Funding

Transposable Element Interaction and Its Impact on Human Development and HealthDP5OD033430 · OD · BROAD INSTITUTE, INC. · PI XIA, BO · 2022 to 2025
$1.9M
High-throughput Discovery of Novel Genome Organization RegulatorsR03OD036495 · OD · BROAD INSTITUTE, INC. · PI XIA, BO · 2023 to 2023
$293k
NIH HHS DP5 OD033430NIH HHS R03 OD036495
6 · The paper itself

Abstract

The vertebrate genome is spatially organized into topologically associating domains (TADs), primarily via cohesin-mediated loop extrusion which typically halts at convergent CTCF binding sites to establish domain boundaries. However, despite the essential roles of CTCF and cohesin in establishing TADs, a long-standing paradox persists: CTCF and cohesin binding sites dramatically outnumber observed TAD boundaries, suggesting the existence of undiscovered architectural factors. To identify such missing factors, we conducted high-resolution

Identifiers

PMID41415375
PMCPMC12709474

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.