ArticlebioRxiv : the preprint server for biology2025
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state.
Elizabeth A Thayer, Gabriela Shipman, Joel Rivera-Cardona, Tarun Mahajan, Qi Wen Teo, J Sebastian Paez, Joseph Lederer, Jie Chen, Nicholas C Wu, Sergei Maslov and 1 more
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Elizabeth A ThayerDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Gabriela ShipmanDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Joel Rivera-CardonaDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Tarun MahajanDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0003-3453-9517
Qi Wen TeoCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
J Sebastian PaezTalus Bioscience, Seattle, WA, USA.
Joseph LedererCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Jie ChenDepartment of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Nicholas C WuCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-9078-6697
Sergei MaslovDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-3701-492X
Christopher B BrookeDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-6815-1193
Funding
Phospholipase D signalingR01GM089771 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHEN, JIE · 2011 to 2025
$3.9M
Biophysical constraints of influenza neuraminidase evolutionR01AI165475 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WU, NICHOLAS C. · 2022 to 2025
$2.0M
The effects of influenza virus genomic heterogeneity on replication dynamics and the host responseR01AI139246 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BROOKE, CHRISTOPHER BYRON · 2018 to 2022
$1.9M
Dissecting the viral and host constraints that govern influenza virus antigenic evolutionR01AI179910 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Christopher Byron Brooke · 2024 to 2026
Type I and III interferons (IFNs) are among the first lines of defense against viral infection, yet they are generally only produced by a tiny fraction of infected cells. Here, we show that cellular heterogeneity in IFN induction potential upon treatment with immunostimulatory RNA is not due to variability in sensing of stimuli but instead is shaped by heterogeneity in tonic cell signaling state. Using complementary single-cell approaches, we found that baseline variation in the c-Jun N-terminal kinase (JNK) and activator protein (AP)-1 transcription factor families correlated with
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state. · full record | Socratic