ReviewFrontiers in oncology2025
Complementary strategies in pancreatic cancer precision medicine: therapeutic prediction and immune modulation.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stem Cell-Derived Organoids for Cancer Therapy: Precision Medicine and Drug Selection.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal with five-year survival below 10%, primarily due to late diagnosis, treatment resistance, and immunosuppressive microenvironment. Methods: This review examines recent advances in PDAC precision medicine by analyzing organoid-based drug screening platforms, mRNA immunotherapy developments, and integrated diagnostic technologies. Results: Patient-derived organoids demonstrate strong predictive value for clinical outcomes, with drug sensitivity profiles correlating with patient responses (concordance >80%). Personalized mRNA neoantigen vaccines induce robust T-cell responses, with vaccine responders showing significantly prolonged recurrence-free survival (median not reached vs. 13.4 months). KRAS-targeted therapies achieve 10-15% response rates in G12C-mutant PDAC. Integration of spatial transcriptomics and liquid biopsy enables real-time molecular monitoring. Conclusions: The development of patient-derived organoids for drug sensitivity testing, personalized mRNA vaccines for immune activation, and precision diagnostic and therapeutic technologies represents complementary advances in PDAC. While each approach has demonstrated independent clinical value, their integration remains an important future direction that may provide a comprehensive framework for improving outcomes in PDAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.