ArticleDrug design, development and therapy2025
Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap forDrug design, development and therapy · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH). Methods: 18β-GA-Lips of varying particle sizes were formulated using the film-dispersion method and the thin-film dispersion-probe ultrasonic technique. Their characteristics, pharmacokinetics, and tissue distribution were thoroughly investigated, followed by an inhalation subacute toxicological analysis. Anti-PAH effects were assessed through hemodynamic measurements, right ventricular hypertrophy evaluation, echocardiography, histomorphometric, and morphological analyses. Results: The 18β-GA-Lips, with varying particle sizes, exhibited a uniform spherical morphology, achieved entrapment efficiencies exceeding 80%, and had average particle sizes ranging from 150 to 1183 nanometers. These were categorized into four distinct size groups. The drug release profile demonstrated favorable sustained-release characteristics in vitro, and the formulation remained stable for up to 15 days when stored at 4°C. Pharmacokinetic analyses revealed that, compared with the 18β-GA-solution group, the AUC Conclusion: These findings confirm that 18β-GA-Lips exhibit outstanding lung-targeting capabilities and lack inhalation toxicity, thereby significantly enhancing the therapeutic efficacy of treatments for PAH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.