ArticleFrontiers in veterinary science2025
Lysozyme supplement enhances antioxidant capacity and regulates liver glucolipid metabolism in weaned piglets.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Introduction: Lysozyme (LZ), a naturally occurring antimicrobial peptide, has demonstrated beneficial bioactivities. This study aimed to investigate the effects of dietary LZ supplementation on hepatic antioxidant function and glucolipid metabolism in weaned piglets. Methods: Forty-eight weaned piglets (Landrace × Yorkshire, 22 days old) were randomly assigned to two dietary treatments: a control (CON) group fed a basal diet, and an LZ group fed the basal diet supplemented with 0.1% LZ for 19 days. Liver index and serum biochemical parameters were measured. Hepatic antioxidant enzyme activities and the mRNA expression of genes related to antioxidant function, lipid metabolism, and gluconeogenesis were determined. Liver fatty acid profiles were also analyzed. Results: Dietary LZ supplementation significantly increased the liver index and serum concentrations of triglyceride (TG), total cholesterol (TC), and Low-Density Lipoprotein Cholesterol (LDLC) ( Discussion: The results indicate that dietary LZ supplementation enhances the hepatic antioxidant defense system, likely through activation of the Nrf2 signaling pathway. Concurrently, LZ modulates lipid metabolism by promoting fatty acid oxidation (via up-regulation of
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