Evidence map›Paper›PMID 41415845›Full record

SynthesisFrontiers in nutrition2025

The effects of

Hayriye Sebnem Harsa, Carmen María González Domenech, Milica Prvulović, Zeynep Agirbasli, Erfan Bagherzadehsurbagh, Valentina Simeunović, Eleni Naziri, Elizabeth Adesemoye, Aycan Yigit Cinar, Arghya Mukherjee and 16 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The effects ofFrontiers in nutrition · 2025
    Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Hayriye Sebnem HarsaDepartment of Food Engineering, Faculty of Engineering, İzmir Institute of Technology, İzmir, Türkiye.
Carmen María González DomenechDepartment of Microbiology, School of Medicine, University of Malaga, Málaga, Spain.
Milica PrvulovićDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Zeynep AgirbasliDepartment of Food Engineering, Faculty of Engineering, İzmir Institute of Technology, İzmir, Türkiye.
Erfan BagherzadehsurbaghDepartment of Food Engineering, Institute of Natural and Applied Sciences, Akdeniz University, Antalya, Türkiye.
Valentina SimeunovićDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Eleni NaziriDepartment of Food Science and Nutrition, School of Environment, University of the Aegean, Lemnos, Greece.
Elizabeth AdesemoyeDepartment of Microbiology, Faculty of Life Sciences, Federal University Oye Ekiti, Ekiti State, Nigeria.
Aycan Yigit CinarDepartment of Food Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Türkiye.
Arghya MukherjeeDepartment of Food Biosciences, Teagasc Food Research Centre, Fermoy, County Cork, Ireland.
Marta LaranjoMED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Departamento de Medicina Veterinária, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal.
Bojana VidovićDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Emilia AlvesCBIOS - Universidade Lusófona's Research Center for Biosciences & Health Technologies, Lisbon, Portugal.
Anđela VukojevićDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Sine Özmen ToğayDepartment of Food Engineering, Faculty of Agriculture, Bursa Uludağ University, Bursa, Türkiye.
Gamze DüvenMilk and Dairy Technology Programme, Department of Food Processing, Karacabey Vocational School, Bursa Uludag University, Bursa, Türkiye.
Helen SaarAS TFTAK Research Services, Tallinn, Estonia.
Seppo SalminenCenter for Food and Nutrition Research, University of Turku, Turku, Finland.
Antonia MatalasDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece.
Diana PaveljšekUniversity of Ljubljana, Biotechnical Faculty, Ljubljana, Slovenia.
Else SchneiderCenter for Affective, Stress and Sleep Disorders, University Psychiatric Clinics (UPK) Basel, Basel, Switzerland.
Timur LiwinskiCenter for Affective, Stress and Sleep Disorders, University Psychiatric Clinics (UPK) Basel, Basel, Switzerland.
Christophe ChassardUCA, INRAE, VetAgro Sup, UMRF, Aurillac, France.
Guy VergèresStrategic Research Division Food Microbial Systems, Functional Nutritional Biology, Agroscope, Bern, Switzerland.
Cornelia BärCompetence Division Methods Development and Analytics, Biochemistry of Milk and Microorganisms, Agroscope, Bern, Switzerland.
Smilja PraćerDepartment of Neurobiology, Institute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Psychobiotics are microorganisms that modulate brain function via the gut-brain axis and are increasingly studied for their cognitive benefits. Methods: We conducted the systematic review following EFSA guidelines, Cochrane methodology, and a PROSPERO protocol, using CADIMA for study selection and data extraction. PubMed, Scopus, and Cochrane Library were searched (1 January 1970-31 August 2023) for human intervention and observational studies assessing cognitive outcomes after ingestion of foods fermented with Results: We included 21 studies (8 interventional, 13 observational). The majority of studies reported benefits, particularly in episodic memory, executive functions, and global cognition, but evidence was limited by inadequate controls, small sample sizes, short interventions, inconsistent domain assessment, and incomplete food characterization. Observational studies had larger populations and longer follow-ups but were limited by exposure assessment and depth of cognitive testing. Conclusion: Consumption of foods fermented with Systematic review registration: This study was registered at the Open Science Framework (10.17605/OSF.IO/Z6GRW).

Indexed as

bioactive metabolitesEFSAepisodic memoryfermented foodfunctional foodgut-brain axismicrobiotapsychobiotics

Identifiers

PMID41415845
PMCPMC12708534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.