Evidence mapPaperPMID 41415848Full record

ArticleFrontiers in nutrition2025

Association between dietary folate intake and gestational diabetes mellitus: evidence from baseline data of a Chinese maternal and infant cohort.

Xiangyi Wu, Rong Zhang, Lu Lu, Rui Fan, Rui Hu, Yue Teng, Lina Pan, Xiaoling Zeng, Wei Jiang, Wei Li and 3 more

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Xiangyi WuDepartment of Nutrition and Food Hygiene, School of Public Health, Health Science Centre, Peking University, Beijing, China.
Rong ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Health Science Centre, Peking University, Beijing, China.
Lu LuGaomi City People's Hospital, Weifang, China.
Rui FanDepartment of Nutrition and Food Hygiene, School of Public Health, Health Science Centre, Peking University, Beijing, China.
Rui HuBeijing Huairou Maternal and Child Health Care Hospital, Beijing, China.
Yue TengBeijing Haidian Maternal and Child Health Hospital, Beijing, China.
Lina PanHunan Ausnutria Institute of Food and Nutrition, Changsha, China.
Xiaoling ZengHunan Ausnutria Institute of Food and Nutrition, Changsha, China.
Wei JiangHunan Ausnutria Institute of Food and Nutrition, Changsha, China.
Wei LiHunan Ausnutria Institute of Food and Nutrition, Changsha, China.
Ling DongHunan Ausnutria Institute of Food and Nutrition, Changsha, China.
Zhaofeng ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Health Science Centre, Peking University, Beijing, China.
Wenli ZhuDepartment of Nutrition and Food Hygiene, School of Public Health, Health Science Centre, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Folate is an essential nutrient during pregnancy, which may contribute to the development of gestational diabetes mellitus (GDM), but the results of existing studies are inconsistent. This study aimed to assess the dietary folate intake among pregnant women and examine its association with GDM. Method: Baseline data from the Mother & Child Nutrition and Health Cohort Study (MCNHC) were used in this cross-sectional analysis, which women with 24-30 weeks of gestation were included. Dietary folate intake was measured and their status was categorized by national guidelines. Methyl-donor nutritional quality index (MNQI) was used as a comprehensive indicator to assess the intake of folate and corelative nutrients in one-carbon metabolism. Binary logistic regression analysis was used to investigate the associations between dietary folate intake and GDM. Results: Among the 368 pregnant women included, 147 women (39.9%) were diagnosed with GDM. The proportion of participants with insufficient dietary folate intake (< 520 μg DFE/d) was 57.5%. While no significant association was observed between dietary folate intake and GDM, the highest odds of GDM was observed in women with combined insufficient vitamin B Discussion: In Conclusion, insufficient dietary folate intake in Chinese pregnant women during the second and third trimesters is rather concerning. It points out an urge for improving the dietary folate intake among pregnant women during this period. It also suggests a potential association between balanced vitamin B

Indexed as

dietary folate intakefolatefolic acid supplementgestational diabetes mellitusmethyl-donor nutritional quality indexone-carbon metabolismvitamin B12

Identifiers

PMID41415848
PMCPMC12709919

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