ArticleJournal of biological methods2025
A systematic computational analysis of pharmacological options in neuroinflammatory-induced autism spectrum disorder in children: A potential for drug repositioning.
Article in Journal of biological methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Systems biology and single-cell transcriptome analysis identify potential therapeutic targets and impaired neurogenesis in human cortical development related to autism spectrum disorder.Molecular diversity · 2026Article
- Mapping Global Research Trends on Autism Spectrum Disorder: A Bibliometric Analysis of Pharmacology and Pharmacy Studies.Pharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and the presence of restricted or repetitive behaviors. Although its underlying pathophysiological mechanisms remain unclear, growing evidence indicates that neuroinflammation plays a significant role, especially in children. Objective: This study aims to explore neuroinflammatory pathways in children aged 12 and under, with a focus on potential therapeutic opportunities through drug repositioning. Methods: We conducted a systematic computational analysis using data from 27 studies and bioinformatics resources such as DrugBank and PubChem, identifying over 8,000 potential drug candidates from the initial 29 treatments retrieved from the literature. Results: Key compounds such as cannabidiol, fluoxetine, and risperidone were highlighted for their broad therapeutic potential. In addition, emerging treatments, including cell-based therapies and dietary interventions, were explored. Conclusion: Our findings support drug repositioning as an effective strategy for developing new ASD treatments during critical developmental periods, emphasizing the need for further research to validate these pathways and the efficacy of innovative therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.