Trends in prescriptions and factors associated with discontinuation of potentially inappropriate medications in elderly patients with advanced cancer at the end of life: A retrospective cohort study.

Shoichi Masumoto, Yu Sun, Mikiya Sato, Kenji Momo, Jun Hamano, Chihiro Nishiura, Kenji Fujimoto, Tetsuhiro Maeno

Abstract read

In one paragraph

Article in Palliative care and social practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shoichi MasumotoDepartment of Family Medicine, General Practice and Community Health, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-7433-1625

Yu SunDepartment of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-3784-4333

Mikiya SatoDepartment of Health Services Research, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-1712-6684

Kenji MomoDepartment of Hospital Pharmaceutics, School of Pharmacy, Showa Medical University, Shinagawa-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9856-0097

Jun HamanoDivision of Clinical Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0003-0304-9881

Chihiro NishiuraDepartment of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-8850-5446

Kenji FujimotoOccupational Health Data Science Center, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.ORCID https://orcid.org/0000-0003-2920-4990

Tetsuhiro MaenoDepartment of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-1574-776X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Potentially inappropriate medications (PIMs) pose a significant burden on patients with advanced cancer approaching the end of life. However, trends in the prescription of PIMs and the factors associated with deprescribing PIMs in these patients remain unclear. Objective: To describe trends in the prescription of PIMs and explore the factors associated with the deprescribing of PIMs in patients with advanced cancer in Japan. Design: Retrospective cohort study using medical claims data. Methods: We analyzed patients aged >65 years who were diagnosed with cancer 6 months before death and died between December 2017 and August 2023 in the city of Mito, Ibaraki prefecture, Japan. Sociodemographic, clinical, and prescription data were collected at 6 months (M6), 3 months (M3), and 1 month (M1) before death. PIMs were assessed according to the OncPal Deprescribing Guidelines. Results: The mean age of 1269 patients was 80.6 years, and 62.2% were male. PIMs were prescribed to 77.0% at M6, 76.4% at M3, and 70.0% at M1 ( Conclusion: In patients with advanced cancer, PIM use decreased as they approached death. Deprescribing PIMs was more common in females, patients with polypharmacy and comorbidities, and patients admitted to hospitals, especially palliative care units.

Indexed as

advanced cancerdeprescribingend-of-life carepalliative carepolypharmacypotentially inappropriate medications

Identifiers

PMID41415902

DOI10.1177/26323524251403020

PMCPMC12708989

What Socratic holds

Textmetadata

LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.