Evidence map›Paper›PMID 41416316›Full record

ArticleCureus2025

Parental Characteristics Associated With Children Born With Neural Tube Defects in Puebla, Mexico.

Israel Enrique Crisanto-López, Daniela Juárez-Melchor, Aurea Vera-Loaiza, Victoria Sánchez-Muñoz, Damara Guieshuba Vergara-Matus, Mariana Ruiz-Calpe, Alan Alberto Pérez-Arzola, Yazmin Hernández-Castañeda, Oscar Olivares-Huerta, Jonathan Cervantes-Larios and 1 more

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Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Israel Enrique Crisanto-LópezDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Daniela Juárez-MelchorDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Aurea Vera-LoaizaDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Victoria Sánchez-MuñozReproductive Biology Laboratory, Biomedical Research Center of the East, Mexican Social Security Institute, Puebla, MEX.
Damara Guieshuba Vergara-MatusReproductive Biology Laboratory, Biomedical Research Center of the East, Mexican Social Security Institute, Puebla, MEX.
Mariana Ruiz-CalpeReproductive Biology Laboratory, Biomedical Research Center of the East, Mexican Social Security Institute, Puebla, MEX.
Alan Alberto Pérez-ArzolaDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Yazmin Hernández-CastañedaDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Oscar Olivares-HuertaDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Jonathan Cervantes-LariosDepartment of Medical Genetics, General Hospital Zone No. 20, Mexican Social Security Institute, Puebla, MEX.
Juan Carlos Flores-AlonsoReproductive Biology Laboratory, Biomedical Research Center of the East, Mexican Social Security Institute, Puebla, MEX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeural tube defects (NTDs) are one of the most common congenital anomalies. NTDs are caused by multiple factors that develop in the intrauterine stage and represent a critical birth defect morbidity and mortality. NTDs may depend on a risk factor modifiable by parents; hence, paternal health is important for transgenerational health, as it contributes half of the genetic material for the development of a new individual.

objectiveThis study aims to describe demographic, biochemical parameters, and seminal characteristics of parents of offspring with NTDs. MATERIAL AND

methodsAt the General Hospital Zone No. 20 in Puebla, Mexico, parents of newborns or children with NTDs were identified. Clinical, toxicological, and environmental histories were obtained to identify risk factors for NTDs. Additionally, they were requested to provide a semen sample for spermiogram and sperm DNA fragmentation analyses.

resultsSix fathers of children with NTDs were evaluated. Half of the offspring presented with meningocele and half with myelomeningocele. The mean paternal age at conception was 29±5.7 years. None reported folic acid supplementation; 83.3% consumed alcohol, 50% used tobacco, and 66.7% were overweight. Semen analysis showed abnormalities in 50% of cases, and all participants exhibited sperm DNA fragmentation. DISCUSSION: Paternal preconception health is critically important for offspring development. Exposure to epigenetic factors such as environmental pollution, chemical endocrine disruptors, poor diet quality, lack of physical activity, alcohol and tobacco use, obesity, and conditions that induce oxidative stress can all compromise sperm quality and the health of progeny.

conclusionBased on our findings, lack of folic acid supplementation, obesity, alcohol consumption, and sperm DNA fragmentation emerged as significant risk factors for the occurrence of NTDs.

Indexed as

congenital abnormalitiesdna fragmentationneural tube defectsreproductive healthspermatozoa

Identifiers

PMID41416316
PMCPMC12709558

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.