Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis.

Taisei Ichihara, Yoshihiro Hayashi, Takuya Sato, Mitsuko Iguchi, Makoto Toi, Hironaga Satake, Ichiro Murakami

Abstract read

In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taisei IchiharaDepartment of Medical Oncology, Kochi Medical School Hospital, Nankoku‑shi, Kochi 783‑8505, Japan.

Yoshihiro HayashiScience Research Center, Kochi University, Nankoku‑shi, Kochi 783‑8505, Japan.

Takuya SatoDepartment of Medical Oncology, Kochi Medical School Hospital, Nankoku‑shi, Kochi 783‑8505, Japan.

Mitsuko IguchiDiagnostic Pathology Department, Kochi Medical School Hospital, Nankoku‑shi, Kochi 783‑8505, Japan.

Makoto ToiDiagnostic Pathology Department, Kochi Medical School Hospital, Nankoku‑shi, Kochi 783‑8505, Japan.

Hironaga SatakeDepartment of Medical Oncology, Kochi Medical School Hospital, Nankoku‑shi, Kochi 783‑8505, Japan.

Ichiro MurakamiDepartment of Pathology, Kochi Medical School, Nankoku‑shi, Kochi 783‑8505, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krebs von den Lungen‑6 (KL‑6), a high‑molecular‑weight glycoprotein, is frequently elevated in patients with cancer; however, its precise role in the clinical progression of breast cancer (BC) remains unclear. Tumor hypoxia has been recognized as a critical driver of cancer progression. The present study aimed to investigate the effects of hypoxia on KL‑6 expression and its contribution to the invasive behavior of BC cells. Immunohistochemical analysis of KL‑6 and hypoxia‑inducible factor‑1α (HIF‑1α) was performed in 30 clinical BC tissue samples, and their expression levels were correlated with patient outcomes. BC cell lines (MCF‑7 and MDA‑MB‑231) were used for

Indexed as

Breast NeoplasmsHypoxia-Inducible Factor 1, alpha SubunitMucin-1Neoplasm Recurrence, LocalAdultAgedBiomarkers, TumorCell HypoxiaCell Line, TumorCell MovementCobaltFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsMiddle AgedBiomarkers, TumorCobaltcobaltous chlorideHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMUC1 protein, humanMucin-1breast cancerHIF‑1αhypoxiainvasionKL‑6metastasisTME

Identifiers

PMID41416421

DOI10.3892/or.2025.9040

PMCPMC12750046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.