Evidence map›Paper›PMID 41416461›Full record

ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2025

The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.

Deborah Finkel, Brian K Finch, Margaret Gatz, Kaare Christensen, Carol E Franz, Ida K Karlsson, William S Kremen, Robert F Krueger, Michelle Lupton, Nicholas Martin and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Deborah Finkel *Center for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-2346-2470
Brian K Finch *Center for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.
Margaret GatzCenter for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.
Kaare ChristensenThe Danish Twin Registry and Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-5429-5292
Carol E FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Ida K KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Michelle LuptonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nicholas MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0003-4069-8020
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Miriam A MosingDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jenae NeiderhiserDepartment of Psychology, The Pennsylvania State University, University Park, Pennsylvania, USA.
Marianne NygaardDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Elizabeth Prom-WorleyDepartment of Epidemiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Chandra ReynoldsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Colorado, USA.
Perminder SachdevCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Elina SillanpääFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Eero VuoksimaaInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Keith E WhitfieldJohns Hopkins Center for Health Disparities Solutions, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.
Orla HaydenCenter for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.
Ellen WaltersCenter for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
IGEMS consortium

Funding

Differences in the association of education with ADRD across countries, historical eras, and men and women.R01AG081248 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$1.3M
Gene-environment Interplay Among Modifiable Factors for AD/ADRD: Risk and Resilience Across the LifespanR01AG089666 · UNIVERSITY OF COLORADO · 2025 to 2025
$732k
NIA NIH HHS R01 AG081248NIA NIH HHS R01 AG089666NIA NIH HHS R21 AG087486
6 · The paper itself

Abstract

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene-environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.

Indexed as

AgingDementiaEarly life adversityGene–environment interplayHealthSocioeconomic status

Identifiers

PMID41416461
PMCPMC13033607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.