Evidence map›Paper›PMID 41416533›Full record

ArticleAnnals of medicine2025

Sarcopenia is a bad harbinger of cancer-related survival in rectal cancer.

Sema Yilmaz Rakici, Rahmi Atil Aksoy, Gulen Burakgazi, Ozlem Terzi, Esra Aydin, Zihni Acar Yazici, Nilgun Ozbek Okumus

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sema Yilmaz RakiciDepartment of Radiation Oncology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye.ORCID 0000-0002-5543-9761
Rahmi Atil AksoyDepartment of Radiation Oncology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye.
Gulen BurakgaziDepartment of Radiology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye.
Ozlem TerziDepartment of Public Health, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkiye.
Esra AydinDepartment of Medical Oncology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye.
Zihni Acar YaziciDepartment of Microbiology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye.
Nilgun Ozbek OkumusDepartment of Radiation Oncology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSarcopenia, characterized by the progressive loss of skeletal muscle mass and function, has been linked to poor oncological outcomes. This study aimed to assess the relationship between sarcopenia-defined through combined radiological and biochemical assessments-and survival outcomes in patients with rectal cancer.

methodsSarcopenia was evaluated using radiological measurements of skeletal muscle mass, visceral and subcutaneous fat tissue volumes, and biochemical parameters including albumin, protein, and Fib-4 index levels.

resultsDeceased patients were older than survivors (mean 70 vs. 63years). Elevated Fib-4 scores (3.0-4.9) were mainly observed in non-operated patients with poor tumor regression. Post-treatment albumin levels were significantly higher in patients with complete response (42.0±3.5mg/dL) than in those with regression score-3 (37.3±8.7mg/dL) and non-operated patients (34.9±8.3mg/dL;

conclusionsSarcopenia is associated with decreased overall survival in rectal cancer. In patients receiving neoadjuvant therapy, lower volumes of muscle mass, subcutaneous fat, and visceral fat, together with lower albumin and protein levels and higher Fib-4 scores, may serve as predictive markers of sarcopenia.

Indexed as

Rectal NeoplasmsSarcopeniaAgedAged, 80 and overFemaleHumansIntra-Abdominal FatMaleMiddle AgedMuscle, SkeletalPrognosisSerum AlbuminSubcutaneous FatSerum Albumincross-section skeletal muscle mass volume measurementpoor survivalRectal cancersarcopeniasubcutaneous fatvisceral fat

Identifiers

PMID41416533
PMCPMC12720608

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.