ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Accelerometer-measured weekend catch-up sleep and incident dementia: A prospective cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Accelerometer-measured weekend catch-up sleep and incident dementia: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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12 authors.
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Abstract
introductionHealthy sleep may support cognitive health, but the role of weekend catch-up sleep is unclear.
methodsAmong 83,776 dementia-free UK Biobank participants aged ≥50 years, sleep duration was estimated from 7-day accelerometer data (2013-2015). Weekend catch-up sleep was defined as the weekend-weekday sleep duration difference. Cox regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause dementia associated with weekend catch-up sleep.
resultsDuring follow-up (median: 8.0 years), 713 participants developed all-cause dementia. Compared with ≤0.5 h, HRs for all-cause dementia across catch-up sleep categories were 0.91 (0.74-1.11) for > 0.5-1 h, 0.64 (0.49-0.86) for > 1-1.5 h, 0.84 (0.60-1.16) for > 1.5-2 h, and 0.83 (0.60-1.16) for > 2 h. The association was stronger among participants with weekday sleep < 8 h (HR: 0.49, 0.29-0.81 for > 1-1.5 h) but non-significant in those with ≥8 h (p-interaction = 0.039). DISCUSSION: Moderate weekend catch-up sleep was linked to lower dementia risk, especially among individuals with less weekday sleep. HIGHLIGHTS: In this prospective cohort study, moderate accelerometer-measured weekend catch-up sleep was linked to a reduced risk of dementia, with 1-1.5 h associated with the lowest risk. The relation was more pronounced in participants with weekday sleep duration < 8 h/day, but non-significant among those with a longer weekday sleep. Similar associations were observed across the subgroups stratified by sociodemographic and lifestyle factors.
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