Evidence map›Paper›PMID 41416935›Full record

ArticleEuropean journal of immunology2025

Beyond FoxP3-Identification of a Chicken Regulatory T Cell Signature.

Isabell Naumann, Edward S Ricemeyer, Daniel Elleder, Jiri Plachy, Dominik von La Roche, Kim Vučinić, Thomas W Göbel, Bernd Kaspers, Simon P Früh, Sonja Härtle

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isabell NaumannDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Edward S RicemeyerBond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
Daniel EllederLaboratory of Viral and Cellular Genetics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Jiri PlachyLaboratory of Viral and Cellular Genetics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Dominik von La RocheDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Kim VučinićLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Thomas W GöbelDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Bernd KaspersDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Simon P FrühDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.
Sonja HärtleDepartment of Veterinary Sciences, AG Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-7957-7827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Tregs), defined by the lineage-specific transcription factor FoxP3, are crucial for immune regulation and have been studied extensively in mammals. However, avian Tregs remain poorly characterized, leaving gaps in our understanding of their evolutionary conservation and unique features. In this study, we investigated the phenotype of chicken Tregs to define reliable markers for their identification and characterization. We analyzed CD4

Indexed as

ChickensForkhead Transcription FactorsT-Lymphocytes, RegulatoryAnimalsCTLA-4 AntigenGlucocorticoid-Induced TNFR-Related ProteinInterleukin-2 Receptor alpha SubunitCTLA-4 AntigenForkhead Transcription FactorsGlucocorticoid-Induced TNFR-Related ProteinInterleukin-2 Receptor alpha SubunitchickenCTLA‐4FoxP3single‐cell RNA‐seqTreg signature

Identifiers

PMID41416935
PMCPMC12716188

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.